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A case of Kounis syndrome associated with branched-chain amino acid supplementation in a 17-year-old boy

Published online by Cambridge University Press:  26 July 2018

Volkan Dogan
Volkan Dogan*
Affiliation:
Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Muğla, Turkey
*
Author for correspondence: V. Dogan, MD, Assistant Professor, Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Muğla, Turkey. Tel: +90 252 212 75 28; Fax: +90 252 212 75 29; E-mail: drvolkandogan@hotmail.com
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Abstract

Kounis Syndrome is characterised by the concurrence of acute coronary syndrome with mast cell activation induced by inflammatory mediators released during an allergic reaction. Although several factors and diseases were reported to be associated with Kounis Syndrome, branched-chain amino acid supplements have not been previously reported as a cause of Kounis Syndrome. We present a 17-year-old boy admitted to our hospital with thoracic pain after the ingestion of a branched-chain amino acid supplement.

Keywords

Kounis syndromebranched-chain amino acidboy
Type
Brief Report
Information
Cardiology in the Young , Volume 28 , Issue 10 , October 2018 , pp. 1165 - 1167
Copyright
© Cambridge University Press 2018 

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References

1. Biteker, M. Current understanding of Kounis syndrome. Expert Rev Clin Immunol 2010; 6: 777–788.Google Scholar
2. Ruiz-Canela, M, Toledo, E, Clish, CB, et al. Plasma branched-chain amino acids and incident cardiovascular disease in the PREDIMED Trial. Clin Chem. 2016; 62: 582–592.Google Scholar
3. Shah, SH, Bain, JR, Muehlbauer, MJ, et al. Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet 2010; 3: 207–214.Google Scholar
4. Bhattacharya, S, Granger, CB, Craig, D, et al. Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization. Atherosclerosis 2014; 232: 191–196.Google Scholar
5. Magnusson, M, Lewis, GD, Ericson, U, et al. A diabetes-predictive amino acid score and future cardiovascular disease. Eur Heart J 2013; 34: 1982–1989.Google Scholar
6. Biteker, M, Biteker, FS, Özlek, B, et al. Classification of Kounis syndrome. Int J Cardiol 2017; 247: 13.Google Scholar
7. Schwartz, LB, Metcalfe, DD, Miller, JS, Earl, H, Sullivan, T. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med 1987; 316: 1622–1626.Google Scholar
8. Grasser, EK, Miles-Chan, JL, Charrière, N, Loonam, CR, Dulloo, AG, Montani, JP. Energy drinks and their impact on the cardiovascular system: potential mechanisms. Adv Nutr 2016; 7: 950–960.Google Scholar
9. Mangi, MA, Rehman, H, Rafique, M, Illovsky, M. Energy drinks and the risk of cardiovascular disease: a review of current literature. Cureus 2017; 9: e1322.Google Scholar