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Are Tp-e interval and QT dispersion values important in children with coeliac disease?

Published online by Cambridge University Press:  24 October 2022

Hakan Birinci Open the ORCID record for Hakan Birinci [Opens in a new window] ,
Canan Yolcu ,
Guzide Dogan ,
Meryem K. Basaran  and
Murat Elevli
Hakan Birinci*
Affiliation:
Department of Pediatrics, Health Science University, Haseki Training and Research Hospital, Istanbul, Turkey
Canan Yolcu
Affiliation:
Department of Pediatric Cardiology, Health Science University, Haseki Training and Research Hospital, Istanbul, Turkey
Guzide Dogan
Affiliation:
Department of Pediatric Gastroentrology, Hepatology and Nutrition, Bezmialem Vakıf University, Istanbul, Turkey
Meryem K. Basaran
Affiliation:
Department of Pediatric Gastroentrology, Hepatology and Nutrition, Gaziosmanpaşa Training and Research Hospital, Istanbul, Turkey
Murat Elevli
Affiliation:
Department of Pediatrics, Health Science University, Haseki Training and Research Hospital, Istanbul, Turkey
*
Author for correspondence: Dr. Hakan Birinci, Department of Pediatrics, Health Science University, Haseki Training and Research Hospital, Sultangazi, Istanbul, Turkey. Tel: +90 212 453 20 00; Fax: +90 212 453 20 00. E-mail: hakanbirinci07@gmail.com
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Abstract

Objectives:

Coeliac disease is an autoimmune intestinal disease that develops with permanent intolerance to gluten and similar cereal proteins. It can damage to many tissues, including myocardium, by autoimmune mechanisms. In our study, we aimed to investigate the effect of coeliac disease on cardiac electrical activity by comparing the Tp-e interval and Qt dispersion values of coeliac patients with healthy children.

Methods:

Fifty-seven coeliac patients and 57 healthy children were included in the study. Sociodemographic findings, physical examinations, symptoms, laboratory values, dietary compliance, endoscopy, and pathological findings were recorded into a standardised form. Electrocardiogram parameters were calculated, and echocardiography findings were noted.

Results:

No statistically significant difference was found between the two groups in terms of age, gender, heart rate, electrocardiogram parameters such as p wave, PR interval, QRS complex, QT interval, and QTc values. Tp-e interval, Tp-e / QT ratio, and Tp-e / QTc ratio were statistically significantly higher in the patient group compared to the control group. Ejection fraction and fractional shortening values were significantly lower in the patient group compared to the control group. In the patient group, Tp-e interval, Tp-e / QT ratio, Tp-e / QTc ratio, and QTc dispersion were statistically significantly higher in patients with tissue transglutaminase IgA positive compared to patients with tissue transglutaminase IgA negative.

Conclusion:

Our study gives important findings in terms of detecting early signs of future cardiovascular events in childhood age group coeliac patients.

Keywords

ChildCoeliac diseaseQT dispersionrepolarisationTp-e
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 10 , October 2023 , pp. 1853 - 1858
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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References

Ludvigsson, JF, James, S, Askling, J, et al. Nationwide cohort study of risk of ischemic heart disease in patients with Celiac disease. Circulation 2011; 123: 483–490.CrossRefGoogle ScholarPubMed
Castro-Torres, Y, Carmona-Puerta, R, Katholi, RE. Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice. World J Clin Cases: WJCC 2015; 3: 705–20.CrossRefGoogle ScholarPubMed
Gupta, P, Patel, C, Patel, H, et al. Tp-e/QT ratio as an index of arrhythmogenesis. J Electrocardiol 2008; 41: 567–574.CrossRefGoogle Scholar
Yan, GX, Antzelevitch, C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998; 98: 1928–1936.CrossRefGoogle ScholarPubMed
Maki, M, Lohi, O. Celiac disease. In: Walker, WA, Goulet, O, Kleinman, RE, tal, e (eds). Pediatric Gastrointestinal Disease, 4th. B.C. Decker, Ontario, 2004: 932–943.Google Scholar
Fasano, A, Catassi, C. Coeliac disease in children. Best Pract Res Clin Gastroenterol 2005; 19: 467–478.CrossRefGoogle ScholarPubMed
Ivarsson, A, Persson, LA, Nystrom, L, et al. Epidemic of coeliac disease in swedish children. Acta Paediatr (Oslo Norway : 1992) 2000; 89: 165–171.CrossRefGoogle Scholar
Fasano, A, Berti, I, Gerarduzzi, T, et al. Prevalence of coeliac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003; 163: 286–292.CrossRefGoogle ScholarPubMed
Ludvigsson, JF, Montgomery, SM, Ekbom, A, et al. Small-intestinal histopathology and mortality risk in Coeliac disease. JAMA 2009; 302: 1171–1178.CrossRefGoogle Scholar
Sari, C, Ertem, AG, Sari, S, et al. Impaired aortic function in patients with Coeliac disease. Kardiol Polska (Pol Heart J) 2015; 73: 1108–1113.CrossRefGoogle ScholarPubMed
Bigger, JT Jr. Relation between left ventricular dysfunction and ventricular arrhythmias after myocardial infarction. Am J Cardiol 1986; 57: 8b–14b.CrossRefGoogle ScholarPubMed
Curione, M, Barbato, M, De Biase, L, et al. Prevalence of coeliac disease in idiopathic dilated cardiomyopathy. Lancet (London England) 1999; 354: 222–223.CrossRefGoogle ScholarPubMed
Lim, PO, Tzemos, N, Farquharson, CA, et al. Reversible hypertension following coeliac disease treatment: the role of moderate hyperhomocysteinaemia and vascular endothelial dysfunction. J Hum Hypertens 2002; 16: 411–415.CrossRefGoogle ScholarPubMed
van Elburg, RM, Uil, JJ, Mulder, CJ, et al. Intestinal permeability in patients with Coeliac disease and relatives of patients with Coeliac disease. Gut 1993; 34: 354–357.CrossRefGoogle ScholarPubMed
Curione, M, Barbato, M, Viola, F, et al. Idiopathic dilated cardiomyopathy associated with coeliac disease : the effect of a gluten-free diet on cardiac performance. Digest Liver Dis: Off J Ital Soc Gastroenterol Ital Assoc Study Liver 2002; 34: 866–869.CrossRefGoogle ScholarPubMed
Peracchi, M, Trovato, C, Longhi, M, et al. Tissue transglutaminase antibodies in patients with end-stage heart failure. Am J Gastroenterol 2002; 97: 2850–2854.CrossRefGoogle ScholarPubMed
Pye, MP, Cobbe, SM. Mechanisms of ventricular arrhythmias in cardiac failure and hypertrophy. Cardiovasc Res 1992; 26: 740–750.CrossRefGoogle ScholarPubMed
Frustaci, A, Cuoco, L, Chimenti, C, et al. Coeliac disease associated with autoimmune myocarditis. Circulation 2002; 105: 2611–2618.CrossRefGoogle ScholarPubMed
Polat, TB, Urganci, N, Yalcin, Y, et al. Cardiac functions in children with Coeliac disease during follow-up: insights from tissue Doppler imaging. Digest Liver Dis 2008; 40: 182–187.CrossRefGoogle ScholarPubMed
Sari, C, A.D., BOLAT, Akin, FE, et al. Assessment of left ventricular function by strain-strain rate echocardiography in patients with Coeliac disease. Turk J Med Sci 2014; 44: 173–177.CrossRefGoogle Scholar
Corazza, G, Frisoni, M, Filipponi, C, et al. Investigation of QT interval in adult Coeliac disease. BMJ: Brit Med J 1992; 304: 1285.CrossRefGoogle ScholarPubMed
Demirtas, K, Yayla, C, Yuksel, M, et al. Tp-e interval and Tp-e/QT ratio in patients with Coeliac disease. Rev Clin Esp 2017; 217: 439–445.CrossRefGoogle Scholar
Libby, P, Ridker, PM, Hansson, GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129–2138.CrossRefGoogle ScholarPubMed
Ede, G, Ibrahim Serin, H, Ede, H, et al. Association between the corrected QT interval, carotid artery intima-media thickness, and hepatic steatosis in obese children. J Clin Res Pediatr Endocrinol 2015; 2: 21–27.Google Scholar
Bornaun, HA, Yilmaz, N, Kutluk, G, et al. Prolonged P-wave and QT dispersion in children with inflammatory bowel disease in remission. Biomed Res Int 2017; 2017, Article ID: 6960810.CrossRefGoogle ScholarPubMed
Amoozgar, H, Ahmadipour, M, Amirhakimi, A. QT dispersion and T wave peak-to-end interval dispersion in children with Kawasaki disease. Int Cardiovasc Res J 2013; 7: 99–103.Google Scholar
Sane, DC, Kontos, JL, Greenberg, CS. Roles of transglutaminases in cardiac and vascular diseases. Front Biosci: J Virtual Lb 2007; 12: 2530–2545.CrossRefGoogle ScholarPubMed
Saylan, B, Cevik, A, Kirsaclioglu, CT, et al. Subclinical cardiac dysfunction in children with Coeliac disease: is the gluten-free diet effective? ISRN Gastroenterol 2012; 2012: 706937.CrossRefGoogle ScholarPubMed