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A case of long QT syndrome associated with familial occurrence of persistent patency of the arterial duct

Published online by Cambridge University Press:  03 May 2005

Subramanian Jothi Murugan ,
Jonathan M. Parsons  and
Chris Bennett
Subramanian Jothi Murugan
Affiliation:
Department of Congenital Heart Disease and Clinical Genetics, Leeds General Infirmary, Leeds, United Kingdom
Jonathan M. Parsons
Affiliation:
Department of Congenital Heart Disease and Clinical Genetics, Leeds General Infirmary, Leeds, United Kingdom
Chris Bennett
Affiliation:
Department of Congenital Heart Disease and Clinical Genetics, Leeds General Infirmary, Leeds, United Kingdom
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Abstract

We describe an occurrence of long QT syndrome in association with persistent patency of the arterial duct in members of a family. Patency of the arterial duct was diagnosed in family members of 4 successive generations. The index case had long QT syndrome associated with such a patent duct. Another patient had long QT syndrome, but associated with a ventricular septal defect. We postulate that there may be a common genetic mechanism for long QT syndrome and persistent patency of the arterial duct.

Keywords

Arrhythmiasductus arteriosusgenetics
Type
Brief Report
Information
Cardiology in the Young , Volume 15 , Issue 3 , June 2005 , pp. 309 - 311
Copyright
© 2005 Cambridge University Press

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References

Moore P, Brook MM, Heymann MA. Patent ductus arteriosus. In: Allen HD, Clark EB, Gutshell HP, Driscoll DJ (eds). Moss and Adams' Heart Disease in Infants, Children, and Adolescents Including the Foetus and Young Adult. Lippincott Williams & Wilkins, Philadelphia, PA, USA, 2001, pp 661.
Hoffman JIE, Kaplan S. The incidence of heart disease. J Am Coll Cardiol 2002; 39: 1890–1900.Google Scholar
Satoda M, Pierpont ME, Diaz GA, Bornemeier RA, Gelb BD. Char Syndrome, an inherited disorder with patent ductus arteriosus, maps to chromosome 6p12-p21. Circulation 1999; 99: 3036–3042.Google Scholar
Sletten LJ, Pierpoint ME. Familial occurrence of patent ductus arteriosus. Am J Med Genet 1995; 57: 27–30.Google Scholar
Moss AJ, Schwartz PJ, Crampton RS, et al. The long QT syndrome: prospective longitudinal study of 328 families. Circulation 1991; 84: 1136–1144.Google Scholar
Marks ML, Whisler SL, Clericuzio C, Keating M. A new form of long QT syndrome associated with syndactyly. J Am Coll Cardiol 1995; 25: 59–64.Google Scholar
Smith GCS. The pharmacology of the ductus arteriosus. Pharmacological Reviews 1998; 50: 35–58.Google Scholar