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Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents

Published online by Cambridge University Press:  20 February 2019

Mehmet Akif Dündar ,
Yasemin Altuner Torun ,
Serkan Fazlı Çelik ,
Emine Kaygı Tartıcı  and
Çiğdem Karakükçü
Mehmet Akif Dündar*
Affiliation:
Department of Pediatrics, Kayseri Training and Research Hospital, Medical Health University, Kayseri, Turkey
Yasemin Altuner Torun
Affiliation:
Division of Pediatric Hematology, Department of Pediatrics, Kayseri Training and Research Hospital, Medical Health University, Kayseri, Turkey
Serkan Fazlı Çelik
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, Kayseri Training and Research Hospital, Medical Health University, Kayseri, Turkey
Emine Kaygı Tartıcı
Affiliation:
Department of Pediatrics, Kayseri Training and Research Hospital, Medical Health University, Kayseri, Turkey
Çiğdem Karakükçü
Affiliation:
Department of Biochemistry, Kayseri Training and Research Hospital, Medical Health University, Kayseri, Turkey
*
Author for correspondence: M. A. Dündar, Kayseri Training and Research Hospital, Medical Health University, 38010 Kocasinan, Kayseri, Turkey. Tel: +905053874085; E-mail: doktordundar1984@gmail.com
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Abstract

Objective

Vitamin B12 deficiency induces hyper-hyperhomocysteinemia by inhibiting intracellular methionine re-methylation. Hyper-hyperhomocysteinemia increases the risk of atherosclerosis. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and its level elevates in cardiovascular diseases. In this study, we aimed to examine the relationship between asymmetric dimethylarginine and arterial stiffness and atherosclerosis in adolescents with vitamin B12 deficiency.

Methods

A total of 88 adolescents with age ranging between 11 and 17 years of age were enrolled for this study. Among them, 50 patients had vitamin B12 deficiency <130 pg/ml and 38 healthy controls had B12 >200 pg/ml. In all cases, the levels of asymmetric dimethylarginine were measured with high performance liquid chromatography method. The carotid artery intima media thickness and left ventricular mass index were measured using echocardiography. All these measurements of the study groups were compared.

Results

Both plasma levels of asymmetric dimethylarginine and carotid artery intima media thickness were significantly higher in the vitamin B12 deficiency group than in the control group. Correlation analysis showed significant negative correlation of vitamin B12 with homocysteine, asymmetric dimethylarginine, and carotid artery intima media thickness (p<0.05).

Conclusion

Our results suggest that endothelial dysfunction starts in the early stage of adolescent vitamin B12 deficiency, and vitamin B12-deficient adolescents have increased circulating asymmetric dimethylarginine, showing that endothelial dysfunction and increased carotid artery intima media thickness be related to atherosclerosis.

Keywords

asymmetric dimethylarginineatherosclerosisvitamin B12 deficiency
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 2 , February 2019 , pp. 190 - 194
Copyright
© Cambridge University Press 2019 

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Footnotes

Cite this article: Dündar MA, Torun YA, Çelik SF, Tartıcı EK, Karakükçü Ç. (2019) Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents. Cardiology in the Young page 190 of 194. doi: 10.1017/S104795111800207X

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