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Is there a possible role for haemostasis in the development of perigraft reaction complicating the modified Blalock Taussig shunt?

Published online by Cambridge University Press:  19 August 2008

Ulrike Salzer-Muhar ,
Ingrid Pabinger-Fasching  and
Sophie Zacherl-Wightman
Ulrike Salzer-Muhar*
Affiliation:
Department of Pediatric Cardiology, General Hospital Vienna, University of Vienna, Austria
Ingrid Pabinger-Fasching
Affiliation:
Department of Haematology and Haemostaseology, General Hospital Vienna, University of Vienna, Austria
Sophie Zacherl-Wightman
Affiliation:
Department of Pediatric Cardiology, General Hospital Vienna, University of Vienna, Austria
*
Ulrike Salzer-Muhar MD, Abteilung für Pediatrische Kardiologie, Univ.-Kinderklinik Wien, Waehringer Guertel 18–20, A–1090 Vienna, Austria. Tel. +43 140 400/3217; Fax +43 140 400/3417; E-mail: ulrike.salzer@akh-wien.ac.at
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Abstract

The perigraft reaction is an unusual complication found in patients in whom a modified Blalock Taussig shunt has been created using a polytetrafluoroethylene graft. We found that, in two infants, consistent laboratory findings during such a perigraft reaction were hypofibrinogenemia, increased levels of thrombin-antithrombin III complex, prothrombinfragment 1 and 2 and products of degradation of fibrin. Normalization of the levels of fibrinogen produced resolution of the perigraft reaction.

Keywords

Modified Blalock Taussig shuntperigraft reactionhealing process of the prosthesisabnormal haemostasis
Type
Brief Reports
Information
Cardiology in the Young , Volume 10 , Issue 3 , May 2000 , pp. 261 - 264
Copyright
Copyright © Cambridge University Press 2000

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