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Left ventricular longitudinal strain and strain rate measurements in paediatric patients in long-term treatment for Chagas disease

Part of: Echocardiography

Published online by Cambridge University Press:  02 March 2021

Alejandro Goldsman Open the ORCID record for Alejandro Goldsman [Opens in a new window] ,
Haydee Vazquez ,
Alberto Quilindro ,
María Sicurello ,
Mariana Cazalas ,
Jaime Altcheh ,
Nicolás González Open the ORCID record for Nicolás González [Opens in a new window] ,
Claudio Moros  and
María Grippo
Alejandro Goldsman*
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
Haydee Vazquez
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
Alberto Quilindro
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
María Sicurello
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
Mariana Cazalas
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
Jaime Altcheh
Affiliation:
Parasitology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
Nicolás González
Affiliation:
Parasitology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
Claudio Moros
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
María Grippo
Affiliation:
Cardiology service Ricardo Gutiérrez Children’s Hospital, Buenos Aires, Argentina
*
Author for correspondence: Dr A. Goldsman, Cardiology service Ricardo Gutiérrez Children’s Hospital, Av. Angel Gallardo 36 8°18, 1405Buenos Aires, Argentina. Tel: +541144179085; Fax: +541148620457. E-mail: agoldsman@hotmail.com
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Abstract

Introduction:

Previous echocardiographic studies failed to show residual alterations of heart function in paediatric patients that have received treatment for Chagas disease. While the echocardiogram is the fundamental front-line tool for evaluating heart function, the appearance of new techniques allows a more detailed analysis. We aimed to evaluate systolic and diastolic function with new techniques in a paediatric population with Chagas disease several years after treatment completion.

Material and methods:

Echocardiograms were obtained from 84 Chagas disease patients (48 female) and 27 healthy controls. All patients had received treatment concluding on average 10 years prior to the study. The prospective analysis considered cardiac dimensions and cardiac function using two-dimensional, M-mode, Doppler and tissue Doppler imaging with emphasis on measuring longitudinal strain in the left ventricle by speckle tracking. Ejection fraction was measured with three-dimensional echocardiography.

Results:

Patients had an age of 14.2 ± 5.7 years (6–33) at the time of evaluation. Global and segmental motility of the left ventricle was normal in all patients. Ejection fraction was 59.2 ± 6.5 and 57.4 ± 6.5% (p = 0.31) in patients and controls respectively. Left ventricular global longitudinal systolic strain was −19 ± 2.4% in patients and −19 ± 3.6% (p = 0.91) in controls. No significant differences were found in remaining systolic and diastolic function measurements.

Conclusions:

Paediatric patients that have received treatment for Chagas disease, evaluated with either conventional techniques or new tools, do not show significant long-term alterations of ventricular function.

Keywords

Chagas diseaseechocardiographyglobal longitudinal straincardiac functionpaediatrics
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 9 , September 2021 , pp. 1451 - 1457
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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