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Trends in prescription of cardiovascular drugs to children in relation to prevalence of CHD from 1999 to 2016

Published online by Cambridge University Press:  11 July 2018

Christian B. Poulsen  and
Mads Damkjær Open the ORCID record for Mads Damkjær [Opens in a new window]
Christian B. Poulsen
Affiliation:
Department of Cardiology, Regional Hospital West Jutland, Herning, Denmark
Mads Damkjær*
Affiliation:
Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark Department of Paediatrics, Kolding Hospital, Kolding, Denmark
*
Author for correspondence: M. Damkjær, MD, PhD, Department of Paediatrics, Kolding Hospital, Skovvangen 4-8, DK-6000 Kolding, Denmark. Tel: +45 20241827; Fax: +45 76362474; E-mail: mads.damkjaer@dadlnet.dk
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Abstract

Introduction

Owing to massive improvements in the diagnostics and surgery of children with CHD, fatality has decreased substantially. As more children with CHD survive from infancy into later childhood, more will need medication for chronic heart failure. However, surprisingly little is actually known about which drugs are being used to treat children with CHD, and whether prescription rates and CHD prevalence have changed over time.

Objective

The objective of this study was to assess the total prescription of cardiovascular drugs to children during an 18-year period and to assess concomitant CHD prevalence.

Methods

All prescription data of cardiovascular drugs to children aged 0–19 years were extracted from publicly available databases in Norway and Denmark from 1999 to 2016. This was coupled with data on CHD prevalence and birth rates.

Results

The number of defined daily doses of cardiovascular drugs prescribed to children doubled in the study period. This was because of an increased use of beta blockers, angiotensin-converting-enzyme inhibitors/angiotensin receptor blockers, and anti-arrhythmic agents. The use of some classes of drugs was significantly reduced over time. The prevalence of CHD remained constant in both countries – 80 per 10,000 births.

Conclusion

We show that there is an increase in the overall prescription of cardiovascular drugs to children. Beta blockers, angiotensin-converting enzyme/angiotensin receptor blockers, and anti-arrhythmics account for the largest increase. Birth rates decreased or remained constant together with CHD prevalence, suggesting that the increased use of cardiovascular drugs reflected increased prescription per patient, rather than more patients receiving a constant amount of drugs.

Keywords

Heart failureCHDpharmacological therapy
Type
Original Article
Information
Cardiology in the Young , Volume 28 , Issue 9 , September 2018 , pp. 1136 - 1141
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Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Poulsen CB, Damkjær M. (2018) Trends in prescription of cardiovascular drugs to children in relation to prevalence of CHD from 1999 to 2016. Cardiology in the Young28: 1136–1141. doi: 10.1017/S1047951118000951

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