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Adult ADHD: Diversion and Misuse of Medications

Published online by Cambridge University Press:  07 November 2014

Thomas J. Spencer
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Extract

In discussions of diversion and misuse of medications in adult attention-deficit/hyperactivity disorder (ADHD), the word “misuse” is intentionally used. Abuse of a medication refers to excessive use of a drug to achieve a “high,” which may result in addiction to the medication and which causes dysfunction in a patient's life. However, misuse refers to usage of a medication without a prescription or for reasons other than that which it was prescribed. Diversion refers to the diverting of legally prescribed medication into illegal use by other than the patient. Sahakian and Morein-Zamir recently discussed the use of cognitive-enhancing drugs by individuals with a variety of disorders as well as off-label and non-prescription use by the general public. In addition to inappropriate use of medications, patients with ADHD often turn to other substances that are detrimental to their health, such as nicotine.

Type
Expert Roundtable Supplement
Information
CNS Spectrums , Volume 13 , Issue S15: Best Practices in Adult ADHD: Special Considerations , October 2008 , pp. 9 - 13
Copyright
Copyright © Cambridge University Press 2008

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References

1.Sahakian, B, Morein-Zamir, S.Professor's little helper. Nature. 2007;450(7173):1157–9.CrossRefGoogle ScholarPubMed
2.Levin, ED, Rezvani, AH.Nicotinic treatment for cognitive dysfunction. Curr Drug Targets CNS Neurol Disord. 2002;1(4):423–431.CrossRefGoogle ScholarPubMed
3.Biederman, J, Monuteaux, MC, Mick, E, et al. Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med. 2006;36(2):167–179.CrossRefGoogle ScholarPubMed
4.Antshel, KM, Faraone, SV, Maglione, K, et al. Temporal stability of ADHD in the high-IQ population: results from the MGH Longitudinal Family Studies of ADHD. J Am Acad Child Adolesc Psychiatry. 2008;47(7):817–25.CrossRefGoogle ScholarPubMed
5.Wilens, TE, Biederman, J, Mick, E, Faraone, SV, Spencer, T.Attention deficit hyperactivity disorder (ADHD) is associated with early onset substance use disorders. J Nerv Ment Dis. 1997;185(8):475–482.CrossRefGoogle ScholarPubMed
6.Biederman, J, Faraone, S, Milberger, S, et al. A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Arch Gen Psychiatry. 1996;53(5):437–46.CrossRefGoogle ScholarPubMed
7.Biederman, J, Faraone, SV, Mick, E, et al.Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry. 1999;38(8):966–75.CrossRefGoogle ScholarPubMed
8.Faraone, SV, Biederman, J, Mick, E, et al. A family study of psychiatric comorbidity in girls and boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2001;50(8):586–92.CrossRefGoogle ScholarPubMed
9.Carroll, KM, Rounsaville, BJ.History and significance of childhood attention deficit disorder in treatment-seeking cocaine abusers. Compr Psychiatry. 1993;34(2):75–82.CrossRefGoogle ScholarPubMed
10.Schubiner, H, Tzelepis, A, Milberger, S, et al. Prevalence of attention-deficit/hyperactivity disorder and conduct disorder among substance abusers. J Clin Psychiatry. 2000;61(4):244–251.CrossRefGoogle ScholarPubMed
11.Levin, FR, Evans, SM, Kleber, HD.Prevalence of adult attention-deficit hyperactivity disorder among cocaine abusers seeking treatment. Drug Alcohol Depend. 1998;52(1):15–25.CrossRefGoogle ScholarPubMed
12.Levin, FR, Evans, SM, Vosburg, SK, Horton, T, Brooks, D, Ng, J.Impact of attention-deficit hyperactivity disorder and other psychopathology on treatment retention among cocaine abusers in a therapeutic community. Addict Behav. 2004;29(9):1875–1882.CrossRefGoogle Scholar
13.Wilens, TE, Biederman, J, Mick, E.Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict. 1998;7(2):156–163.Google ScholarPubMed
14.Wilens, TE.Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. Psychiatr Clin North Am. 2004;27(2):283–301.CrossRefGoogle ScholarPubMed
15.Riggs, PD.Clinical approach to treatment of ADHD in adolescents with substance use disorders and conduct disorder. J Am Acad Child Adolesc Psychiatry. 1998;37(3):331–332.CrossRefGoogle ScholarPubMed
16.Kessler, RC, Adler, L, Barkley, R, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–723.CrossRefGoogle ScholarPubMed
17.Monuteaux, MC, Spencer, TJ, Faraone, SV, Wilson, AM, Biederman, J.A randomized, placebo-controlled clinical trial of bupropion for the prevention of smoking in children and adolescents with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2007 Jul;68(7):1094–101.CrossRefGoogle ScholarPubMed
18.Kollins, SH, MacDonald, EK, Rush, CR.Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review. Pharmacol Biochem Behav. 2001;68(3):611–627.CrossRefGoogle ScholarPubMed
19.Gerasimov, MR, Franceschi, M, Volkow, ND, et al. Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study. J Pharmacol Exp Ther. 2000;295(1):51–7.Google ScholarPubMed
20.Biederman, J, Wilens, T, Mick, E, Spencer, T, Faraone, SV.Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics. 1999;104(2):e20.CrossRefGoogle ScholarPubMed
21.Lambert, NM, Hartsough, CS.Prospective study of tobacco smoking and substance dependencies among samples of ADHD and non-ADHD participants. J Learn Disabil. 1998;31(6):533–544.CrossRefGoogle ScholarPubMed
22.Wilens, TE, Faraone, SV, Biederman, J, Gunawardene, S.Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics. 2003;111(1):179–185.CrossRefGoogle ScholarPubMed
23.Barkley, RA, Fischer, M, Smallish, L, Fletcher, K.Does the treatment of attention-deficit/ hyperactivity disorder with stimulants contribute to drug use/abuse? A 13-year prospective study. Pediatrics. 2003;111(1):97–109.CrossRefGoogle ScholarPubMed
24.Wilens, TE, Adler, LA, Adams, J, et al. Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Adolesc Psychiatry. 2008;47(1):21–31.CrossRefGoogle ScholarPubMed
25.Wilens, TE, Adamson, J, Sgambati, S, Whitley, J, Santry, A, Monuteaux, MC, Biederman, J.Do individuals with ADHD self-medicate with cigarettes and substances of abuse? Results from a controlled family study of ADHD. Am J Addict. 2007;16(suppl 1):14–21.CrossRefGoogle ScholarPubMed
26.Teter, CJ, McCabe, SE, Cranford, JA, Boyd, CJ, Guthrie, SK.Prevalence and motives for illicit use of prescription stimulants in an undergraduate student sample. J Am Coll Health. 2005;53(6):253–262.CrossRefGoogle Scholar
27.McCabe, SE, Knight, JR, Teter, CJ, Wechsler, H.Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey. Addiction. 2005;100(1):96–106.CrossRefGoogle ScholarPubMed
28.Wilens, TE, Gignac, M, Swezey, A, Monuteaux, MC, Biederman, J.Characteristics of adolescents and young adults with ADHD who divert or misuse their prescribed medications. J Am Acad Child Adolesc Psychiatry. 2006;45(4):408–414.CrossRefGoogle ScholarPubMed