Hostname: page-component-77c89778f8-m42fx Total loading time: 0 Render date: 2024-07-19T15:26:50.000Z Has data issue: false hasContentIssue false

Obsessive-Compulsive Disorder With and Without Tic Disorder: A Comparative Study From India

Published online by Cambridge University Press:  07 November 2014

Abstract

Introduction: Evidence from phenomenological, family, genetic, and treatment studies from Western centers have suggested that tic-related obsessive-compulsive disorder (OCD) could be different from non-tic-related OCD. This study from India investigated the differences in OCD with and without tics, with respect to sociode-mographics, symptom profile, and comorbidity, including obsessive-compulsive spectrum disorders, to examine whether the clinical profile of tic-related OCD is similar to that reported previously.

Methods: Fifty subjects with OCD and tics (chronic motor tics and Tourette syndrome) were compared with 141 OCD subjects without tics.

Results: Subjects having OCD with tics tended to be males, and had an earlier onset of illness. They had more of symmetry/aggressive and religious obsessions, and cleaning, ordering/arranging, hoarding, and repeating compulsions and were associated with trichotillomania and hypochondraisis. Stepwise backward (Wald) regression analysis showed that an early age of onset, male gender, aggressive obsessions, cleaning compulsions, and trichotillomania were significantly associated with tic-related OCD.

Conclusion: The findings of this study from India are broadly similar to those reported previously from the West indicating the universality of differences in tic- and non-tic-related OCD. Our findings also support the existing evidence that tics contribute to the heterogeneity of OCD.

Type
Original Research
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Bienvenu, OJ, Samuels, JF, Riddle, MA, et al.The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biol Psychiatry. 2000;48:287293.CrossRefGoogle ScholarPubMed
2.Jaisoorya, TS, Janardhan Reddy, YC, Srinath, S. The relationship of obsessive-compulsive disorder to putative spectrum disorders: results from an Indian study. Compr Psychiatry. 2003;44:317323.CrossRefGoogle ScholarPubMed
3.Geller, DA, Biderman, J, Jones, J, et al.Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of pediatric literature. J Am Acad Child Adolesc Psychiatry. 1998;37:420427.Google Scholar
4.Leckman, JF, Grice, DE, Barr, LC, et al.Tic-related vs non-tic-related obsessive-compulsive disorder. Anxiety. 1995;1:208215.Google Scholar
5.Leonard, HL, Lenane, MC, Swedo, SE, Rettew, DC, Gershon, ES, Rapoport, JL. Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children. Am J Psychiatry. 1992;149:12441251.Google Scholar
6.Mataix-Cols, D, Rauch, SL, Manzo, PA, Jenike, MA, Baer, L. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry. 1999;156:14091416.CrossRefGoogle ScholarPubMed
7.George, MS, Trimble, MR, Ring, HA, Sallee, FR, Robertson, MM. Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourette's syndrome. Am J Psychiatry. 1993;150:9397.Google Scholar
8.Holzer, J, Goodman, WK, Price, LH, et al.Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. Br J Psychiatry. 1994;164:469473.Google Scholar
9.Rasmussen, SA, Tsuang, MT. Clinical characteristics and family history in DSM-III obsessive-compulsive disorder. Am J Psychiatry. 1986;143:317322.Google Scholar
10.Zohar, AH, Pauls, DL, Ratzone, G, et al.Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents. Am J Psychiatry. 1997;154:274276.Google Scholar
11.Petter, T, Margaret, A, Richter, MD, Sandor, P. Clinical features distinguishing patients with Tourette's syndrome and obsessive-compulsive disorder from patients with obsessive-compulsive disorder without tics. J Clin Psychiatry. 1998;59:456459.CrossRefGoogle ScholarPubMed
12.Cath, DC, Spinhoven, P. Hoogduin, CAL, et al.Repetitive behaviours in Tourette's syndrome and OCD with and without tics: what are the differences? Psychiatry Res. 2001;101:171185.Google Scholar
13.Mahgoub, OM, Abdel-Hafeiz, HB. Pattern of obsessive-compulsive disorder in eastern Saudi Arabia. Br J Psychiatry. 1991;158:840842.Google Scholar
14.Okasha, A, Saad, A, Khalil, AH, el Dawla, AS, Yehia, N. Phenomenology of obsessive-compulsive disorder: a transcultural study. Compr Psychiatry. 1994;35:191197.Google Scholar
15.Reddy, PS, Reddy, YC, Srinath, S, Khanna, S, Sheshadri, SP. Girimaji, SR. A family study of juvenile obsessive-compulsive disorder. Can J Psychiatry. 2001;46:346351.Google Scholar
16.Khanna, S, Guruswamy, R. A clinical genetic study of obsessive-compulsive disorder from India [abstract]. Am J Med Genet. 1997;74:651652.Google Scholar
17.Khanna, S, Channabasavanna, SM. Phenomenology of obsessions in obsessive-compulsive neurosis. Psychopathology. 1988;21:1218.CrossRefGoogle ScholarPubMed
18.Akhtar, S, Wig, NN, Varma, VK, Pershad, D, Verma, SK. A phenomenological analysis of symptoms in obsessive-compulsive neurosis. Br J Psychiatry. 1975;127:342348.Google Scholar
19.Khanna, S, Kaliaperumal, VG, Channabasavanna, SM. Clusters of obsessive-compulsive phenomenon in obsessive-compulsive disorder. Br J Psychiatry. 1990;156:5154.CrossRefGoogle Scholar
20.Girishchandra, BG, Khanna, S. Phenomenology of obsessive-compulsive disorder: a factor analytic approach. Indian J Psychiatry. 2001;43:306318.Google Scholar
21.Ravi Kishore, V, Samar, R, Janardhan Reddy, YC, Chandrasekhar, CR, Thennarasu, K. Clinical characteristics and treatment response in poor and good insight obsessive-compulsive disorder. Eur Psychiatry. 2004;19:202208.Google Scholar
22.Janardhan Reddy, YC, Jaideep, T, Khanna, S. Obsessive-compulsive disorder research in India. In: Ling, BE, ed. Obsessive-Compulsive Disorder Research. New York, NY: Nova Science Publishers; 2005:93120.Google Scholar
23.Rasmussen, SA, Eisen, JL. The epidemiology and clinical features of obsessive-compulsive disorder. Psychiatr Clin North Am. 1992;15:743756.Google Scholar
24.Hanna, GL, Piacentini, J, Cantwell, DP, Fischer, DJ, Himle, JA, Van Etten, M. Obsessive-compulsive disorder with and without tics in a clinical sample of children and adolescents. Depress Anxiety. 2002;16:5963.Google Scholar
25.Hollander, E, Wong, CM. Obsessive-compulsive spectrum disorders. J Clin Psychiatry. 1995;56(suppl 4):36.Google ScholarPubMed
26.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC; American Psychiatric Association; 1994.Google Scholar
27.Golden, GS. Tics and Tourette's: a continuum of symptoms? Ann Neurol. 1978;4:145148.CrossRefGoogle ScholarPubMed
28.Pauls, DL, Pakstis, AJ, Kurlan, R, et al.Segregation and linkage analysis of Tourette's syndrome and related disorders. J Am Acad Child Adolesc Psychiatry. 1990;29:195203.CrossRefGoogle ScholarPubMed
29.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989;46:10061011.Google Scholar
30.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry. 1989;46:10121016.Google Scholar
31.Pauls, DL, Hurst, CR. Schedule for Tourette and Behavioral Syndromes: Adult version A3. Yale Family Genetic Study of Tourette Syndrome. New Haven, Conn: Yale Child Study Center; 1996.Google Scholar
32.Pauls, DL, Hurst, CR. Schedule for Tourette and Behavioral Syndromes: Child version C3. Yale Family Genetic Study of Tourette Syndrome. New Haven, Conn: Yale Child Study Center; 1996.Google Scholar
33.First, MB, Spitzer, RL, Gibbon, M, Williams, JBW. Structured Clinical Interview for DSM-IV Axis I Disorders – Patient edition (SCID-I/P, version 2.0). New York, NY: New York State Psychiatric Institute, Biometrics Research Department; 1995.Google Scholar
34.Kaufman, J, Birmaher, B, Brent, D, Rao, U, Ryan, N. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36:980988.Google Scholar
35. Statistical Package for Social Sciences 15.0 for Windows. Chicago, III: SPSS, Inc.; 2006.Google Scholar
36.Miguel, EC, Baer, L, Coffey, BJ, et al.Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome. Br J Psychiatry. 1997;170:140145.CrossRefGoogle ScholarPubMed
37.Akhtar, S, Wig, N, Varma, VK, Pershad, D, Verma, SK. Socio-cultural and clinical determinants of symptomatology in obsessional neurosis. Int J Soc Psychiatry. 1978;24:157162.Google Scholar
38.Akhtar, S. Obsessional neurosis, marriage, sex, and personality: some transcultural comparisons. Int J Soc Psychiatry. 1978;24:164166.Google Scholar
39.de Silva, P, Bhugra, D. Culture and obsessive-compulsive disorder. In: Bhugra, D, Bhui, K, eds. Textbook of Cultural Psychiatry. New York, NY: Cambridge University Press; 2007:282291.Google Scholar
40.de Groot, CM, Botndyrin, TS, Janus, MD, Mavissakalian, MR. Patterns of obsessive-compulsive symptoms in Tourette subjects are independent of severity. Anxiety. 1995;1:268274.Google Scholar
41.Peterson, BS, Pine, DS, Cohen, P, Brook, JS. Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry. 2001;40:685695.Google Scholar
42.Comings, DE, Comings, BG. Tourette's syndrome and attention deficit disorder with hyperactivity: are they genetically related? J Am Acad Child Adolesc Psychiatry. 1984;23:138146.CrossRefGoogle ScholarPubMed