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Phenotypic Variability in Obsessive-Compulsive Disorder and Its Relationship to Familial Risk

Published online by Cambridge University Press:  07 November 2014

David L. Pauls
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Abstract

Twin and family studies of obsessive-compulsive disorder (OCD) have gleaned important data regarding the influence of genetic factors in the development of this disorder. These studies have shown that understanding the importance of genetic factors in OCD is largely dependent upon how the phenotype is classified. The last decade of research has found that substantial variability of symptomatology exists across individuals diagnosed with OCD. Considering this, a number of analyses have been conducted to determine if possible subtypes of OCD exist, including analysis of age of onset, cluster analysis, factor analysis, and segregation analysis. These methodologies, and possibly others, could aid in identifying the genes involved in the development of OCD.

Type
Feature Articles
Information
CNS Spectrums , Volume 4 , Issue 6: Molecular Genetics: Part Two , June 1999 , pp. 57 - 61
Copyright
Copyright © Cambridge University Press 1999

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References

REFERENCES

1.Alsobrook, JP II, Pauls, DL. The genetics of obsessive-compulsive disorder. In: Jenike, MA, Baer, L, Minichiello, WE, eds. Obsessive-Compulsive Disorders: Theory and Management: A Guide for Clinicians, Patients and Families. 3rd ed. Littleton, Mass: Year Book Medical Publishers, Ine; 1998:Google Scholar
2.Rasmussen, SA, Tsuang, MT. Clinical characteristics and family history in DSM-III obsessive-compulsive disorder. Am J Psychiatry. 1986;143:317–322.Google ScholarPubMed
3.Carey, G, Gottesman, II. Twin and family studies of anxiety, phobic and obsessive disorders. In: Klien, DF, Rabkin, J, eds. Anxiety: New Research and Changing Concepts. New York, NY: Raven Press; 1981:117–136.Google Scholar
4.Clifford, CA, Murray, RM, Fulker, DW. Genetic and environmental influences on obsessional traits and symptoms. Psychol Med. 1984;14:791–800.CrossRefGoogle ScholarPubMed
5.Andrews, G, Stewart, G, Allen, R, Henderson, AS. The genetics of six neurotic disorders: a twin study. J Affect Disord. 1990;19:23–29.CrossRefGoogle ScholarPubMed
6.Lenane, MC, Swedo, SE, Leonard, H, Pauls, DL, Sceery, W, Rapoport, J. Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder. J Am Acad Child Adolesc Psychiatry. 1990;29:407–412.CrossRefGoogle ScholarPubMed
7.Leonard, HL, Lenane, MC, Swedo, SE, Rettew, DC, Gershon, ES, Rapoport, JL. Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children. Am J Psychiatry. 1992;149:1244–1251.Google ScholarPubMed
8.Bellodi, L, Sciuto, G, Diaferia, G, Ronchi, P, Smeraldi, E. Psychiatrie disorders in the families of patients with obsessive-compulsive disorder. Psychiatry Res. 1992;42:111–120.CrossRefGoogle ScholarPubMed
9.Black, DW, Noyes, R Jr, Goldstein, RB, Blum, N. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49:362–368.CrossRefGoogle ScholarPubMed
10.Pauls, DL, Alsobrook, JP II, Goodman, W, Rasmussen, S, Leckman, JF. A family study of obsessive-compulsive disorder. Am J Psychiatry. 1995;152:76–84.Google ScholarPubMed
11.Karno, M, Golding, JM, Sorenson, SB, Bumam, MA. The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry. 1988;45:1084–1099.CrossRefGoogle ScholarPubMed
12.Leboyer, M, Bellivier, F, Nosten-Bertrand, M, Jouvent, R, Pauls, D, Mallet, J. Psychiatric genetics: search for phenotypes. Trends Neurosci. 1998;21:102–105.CrossRefGoogle ScholarPubMed
13.Eapen, V, Robertson, MM, Alsobrook, JP II, Pauls, DL. Obsessive compulsive symptoms in Gilles de la Tourette's syndrome and obsessive compulsive disorder: differences by diagnosis and family history. Am J Med Genet. 1997;74:432–438.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
14.Alsobrook, JP II.A Family and Molecular Genetic Study of Obsessive-Compulsive Disorder [dissertation]. New Haven, Conn: Yale University; 1996.Google Scholar
15.Leckman, JF, Grice, DE, Boardman, J,et al.Symptoms of obsessive-compulsive disorder. Am J Psychiatry. 1997;154:911–917.Google ScholarPubMed
16.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive Compulsive Scale (Y-BOCS), part I: development, use, and reliability. Arch Gen Psychiatry. 1989;46:1006–1011.CrossRefGoogle Scholar
17.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), part II: validity. Arch Gen Psychiatry. 1989;46:1012–1016.CrossRefGoogle Scholar
18.Baer, L. Factor analysis of symptom subtypes of obsessive compulsive disorder and their relation to personality and tics. J Clin Psychiatry. 1993;55:18–23.Google Scholar
19.Summerfeldt, LJ, Richter, MA, Antony, MM, Swinson, RP. Symptom structure in obsessive-compulsive disorder: a confirmatory factor-analytic study. Behav Res Ther. In press.Google Scholar
20.Alsobrook, JP II, Leckman, JF, Goodman, WK, Rasmussen, SA, Pauls, DL. Segregation analysis of obsessive-compulsive disorder using symptom-based factors. Am J Med Genet. In press.Google Scholar
21.Grigorenko, EL, Wood, FB, Meyer, MS, et al.Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. Am J Hum Genet. 1997;60:27–39.Google ScholarPubMed