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Effect of omeprazole and ranitidine on total carbon dioxide concentration in horses subjected to a simulated race test

Published online by Cambridge University Press:  19 October 2009

Denise Ciolino ,
Robert A Lehnhard  and
Kenneth H McKeever
Denise Ciolino
Affiliation:
Department of Animal Science, Equine Science Center, Rutgers, The State University of New Jersey, New Brunswick, NJ08901, USA
Robert A Lehnhard
Affiliation:
Department of Kinesiology, University of Maine, Orono, ME04469, USA
Kenneth H McKeever*
Affiliation:
Department of Animal Science, Equine Science Center, Rutgers, The State University of New Jersey, New Brunswick, NJ08901, USA
*
*Corresponding author: mckeever@aesop.rutgers.edu
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Abstract

The purpose of this study was to test the hypothesis that the gastric ulcer medications, ranitidine and omeprazole, would alter plasma concentrations of total carbon dioxide (tCO2), lactate (LA), Na+, K+, Cl−  and total protein (TP), as well as calculated plasma strong ion difference (SID) and packed cell volume (PCV) in horses subjected to a simulated race test (SRT). Twelve unfit Standardbred mares (~520 kg, 9–18 years) were used in a randomized crossover design with the investigators blind to the treatment given. Each mare received a treatment three times daily (TID) at 06.30, 12.30 and 18.30 hours. The treatments administered orally were omeprazole (4 mg kg− 1 was given in the morning with apple sauce given at the later, two dosing times to encourage good behaviour), ranitidine (6 mg kg− 1 crushed and mixed in 20 ml apple sauce) and control (20 ml apple sauce TID). Each horse completed a series of SRTs with blood samples taken via jugular venipuncture at five intervals (prior to receiving treatment, prior to SRT, immediately following exercise and at 60 and 90 min post-SRT). During the SRTs, each horse ran on a treadmill fixed on a 6% grade for 2 min at a warm-up speed (4 m s− 1) and then for 2 min at a velocity predetermined to produce VO2max. Each horse then walked at 4 m s− 1 for 2 min to complete the SRT. Plasma tCO2, electrolytes, LA and TP concentrations and PCV–TP were measured in duplicate at all intervals. No differences (P>0.05) were detected between control, ranitidine or omeprazole for any of the measured variables. There were differences (P < 0.05) in tCO2, SID, PCV, TP, LA and electrolyte concentrations relative to sampling time. However, these differences were attributable to the physiological pressures associated with acute exercise and not an effect of the medication. It was concluded that ranitidine or omeprazole did not alter plasma tCO2 concentration.

Keywords

ranitidineomeprazoletotal carbon dioxidestrong ion differenceacid–base status
Type
Research Paper
Information
Comparative Exercise Physiology , Volume 6 , Issue 2 , May 2009 , pp. 81 - 87
Copyright
Copyright © Cambridge University Press 2009

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References

1 Rose, RJ and Lloyd, DR (1992). Sodium bicarbonate: more than just a milkshake? Equine Veterinary Journal 24: 75–76.Google Scholar
2 Irvine, CHG (1992). Control of administration on sodium bicarbonate and other alkalis: the New Zealand experience. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, LA, USA, pp. 139–143.Google Scholar
3 Lloyd, DR, Reilly, P and Rose, RJ (1992). The detection and performance effects of sodium bicarbonate administration in the racehorse. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, LA, USA, pp. 131–138.Google Scholar
4 Lloyd, DR and Rose, RJ (1995). Effects of sodium bicarbonate on acid–base status and exercise capacity. Equine Veterinary Journal, Supplement 18: 323–325.Google Scholar
5 Lloyd, DR and Rose, RJ (1992). Issues relating to the use of products that can produce metabolic alkalosis prior to racing. Australian Equine Veterinary Journal 10: 27–28.Google Scholar
6 Schott, HC and Hinchcliff, KW (1993). Fluids, electrolytes, and bicarbonate. Veterinary Clinics of North America, Equine Practice: Drug Use in Performance Horses. vol. 9 Philadelphia, PA: W.B. Saunders, pp. 577–604.Google Scholar
7 Auer, DE, Skelton, KV, Tay, S and Baldock, FC (1993). Detection of bicarbonate administration (milkshake) in Standardbred horses. Australian Veterinary Journal 70: 336–340.Google Scholar
8 Slocumbe, R, Huntington, P, Lind, KL and Vine, JL (1995). Plasma total CO2 and electrolytes: diurnal changes and effects of adrenaline, doxapram, rebreathing, and transport. Equine Veterinary Journal, Supplement 18: 331–336.Google Scholar
9 Lorimer, P (1998). Report of the NJ State Police Racing Commission Drug Detection Laboratory to the New Jersey Racing Commission, 1–3.Google Scholar
10 Frey, LP, Kline, KH, Foreman, JH, Brady, AH and Cooper, SR (1995). Effects of warming-up, racing and sodium bicarbonate in Standardbred horses. Equine Veterinary Journal, Supplement 18: 310–313.Google Scholar
11 Frey, LP, Kline, KH, Foreman, JH, Lyman, JT and Butadom, P (1999). Effects of alternate alkalinizing compounds on blood plasma acid–base balance in exercising horses. Proceedings of the 16th Equine Nutrition and Physiology Society Symposium, Raleigh, NC, USA, June 2–5, pp. 161–162.Google Scholar
12 Greene, AM, Kline, KH and Foreman, JH (1999). Comparison of three blood gas machines for determination of plasma tCO2 in horses administered sodium bicarbonate. Proceedings of the 16th Equine Nutrition and Physiology Society Symposium, Raleigh, NC, USA, pp. 380.Google Scholar
13 Kauffman, KF, Kline, KH, Foreman, JH and Lyman, JT (1999). Effects of diet on plasma tCO2 in horses. Proceedings of the 16th Equine Nutrition and Physiology Society Symposium, Raleigh, NC, USA, pp. 363–364.Google Scholar
14 Szucsik, AM, Baliskonis, VB and McKeever, KH (2006). Effect of seven common supplements on plasma total carbon dioxide concentration and strong ion difference in Standardbred horses subjected to a simulated race test. Equine and Comparative Exercise Physiology 3: 37–44.Google Scholar
15 McKeever, KH, Szucsik, AM, Balaskonis, VB, Betros, CL, Kearns, CF and Malinowski, K (2002). Effect of management practices and training on plasma tCO2 concentration in horses. Journal Animal Science 80: 172.Google Scholar
16 Murray, MJ, Grodinskey, C, Anderson, CW, Radue, PF and Schmidt, GR (1989). Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs. Equine Veterinary Journal, Supplement 7: 68–72.Google Scholar
17 Murray, MJ and Eichorn, ES (1996). Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confinement with ad libitum access to hay on gastric ulceration in horses. American Journal of Veterinary Research 57: 1599–1603.Google Scholar
18 Andrews, FM, Sifferman, RL, Bernard, W, Hughes, FE, Holste, JE, Daurio, CP, et al. (1999). Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine Veterinary Journal, Supplement 29: 81–86.CrossRefGoogle Scholar
19 McKeever, JH, McKeever, KH, Albeirci, JM, Gordon, ME and Manso Filho, HC (2006). Effect of omeprazole on markers of performance in gastric ulcer-free Standardbred horses. Equine Veterinary Journal, Supplement 36: 668–671.Google Scholar
20 Freestone, JF, Carlson, GP, Harrold, DR and Church, G (1989). Furosemide and sodium bicarbonate-induced alkalosis in the horse and response to oral KCl or NaCl therapy. American Journal of Veterinary Research 50: 1334–1339.Google Scholar
21 McKeever, KH (2005). Can feed cause a positive blood test in racehorses? Some recent information on the effect of dietary supplements on plasma tCO2 concentration in horses. In: Pagan, JD (ed.) Advances in Equine Nutrition III. Nottingham: Nottingham University Press, pp. 68–76.Google Scholar
22 Stewart, PA (1978). Independent and dependent variables of acid–base control. Respiration Physiology 33: 9–26.Google Scholar
23 Constable, PD (1997). A simplified strong ion model for acid–base equilibria: application to horse plasma. Journal of Applied Physiology 83: 297–311.Google Scholar
24 Miller, PA and Lawrence, LM (1986). Changes in equine metabolic characteristics due to exercise fatigue. American Journal of Veterinary Research 47: 2184–2186.Google ScholarPubMed
25 Hodgson, DR and Rose, RJ (1994). Athletic Horse. Philadelphia, PA: W.B. Saunders, pp. 63–78.Google Scholar
26 Hyyppa, S and Poso, AR (1998). Fluid, electrolyte, and acid–base responses to exercise in horses. Veterinary Clinics of North America: Equine Practice 14: 121–136.Google Scholar
27 McKeever, KH, Hinchcliff, KW, Reed, SM and Robertson, JT (1993). Role of decreased plasma volume in hematocrit alterations during incremental treadmill exercise in horses. American Journal of Physiology 265: R404–R408.Google Scholar
28 McKeever, KH (2004). Body fluids and electrolytes: responses to exercise and training. In: Hinchcliff, KW, Kaneps, A and Geor, R (eds) Equine Sports Medicine and Surgery: Basic and Clinical Sciences of the Equine Athlete. Chapter 38, Philadelphia, PA: Elsevier, pp. 853–871.CrossRefGoogle Scholar
29 Caltibilota, TJ, Milizio, JG, Malone, SR, Kenney, J and McKeever, KH (2008). Effect of Sucralfate® on plasma total carbon dioxide concentration in horses subjected to a simulated race test. The Veterinary Journal doi: 10.1016/j.tvjl.2008.09.003 (In press).Google Scholar