In order to validate the movement problems in daily life for girls with Turner syndrome (TS), as reported by teachers, parents, and the girls themselves, we examined whether these girls have impaired motor ability and a specific pattern of motor impairment. As TS phenotypes are characterized by a particular profile of normal Verbal IQ (VIQ) and lowered Performance IQ (PIQ), we investigated whether there is a significant correlation between intelligence scores and motor performance scores. Fifteen girls with TS (age range 5.8 to 12.5 years), of whom nine had 45XO karyotype and six girls mosaic karyotype, were individually tested on the Movement Assessment Battery for Children (MABC; Henderson and Sugden 1992, Smits-Engelsman 1998), and the Wechsler Intelligence Scale-Revised (WISC-RN; Vander Steene et al. 1986). Mean percentile score on the MABC was 2.93 (range 1 to 8). Based on the total score of the MABC, none of the girls with TS fell into the ‘normal’ range; five patients were classified as ‘at risk’ and 10 as ‘impaired’. Girls with TS made more errors and needed more time across all items tested; no specific profile of impairment was observed and no significant correlation between intelligence scores and motor performance scores was found. The results clearly demonstrate that girls with TS indeed experience a significant general motor impairment. The motor problems apparently cannot be attributed to cognitive problems.