Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-19T03:27:32.188Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of secretin on children with autism: a randomized controlled trial

Published online by Cambridge University Press:  13 February 2001

Jennifer Dunn-Geier ,
Helena H Ho ,
Edward Auersperg ,
David Doyle ,
Linda Eaves ,
Carey Matsuba ,
Elaine Orrbine ,
Ba' Pham  and
Sharon Whiting
Jennifer Dunn-Geier
Affiliation:
Child Development Service, Children's Hospital of Eastern Ontario, Ontario, Canada.
Helena H Ho
Affiliation:
Department of Pediatrics, University of British Columbia, British Columbia, Canada.
Edward Auersperg
Affiliation:
Ridge Meadows Hospital, Maple Ridge, British Columbia, Canada.
David Doyle
Affiliation:
Child Development Service, Children's Hospital of Eastern Ontario, Ontario, Canada.
Linda Eaves
Affiliation:
Sunny Hill Health Centre for Children, Children's and Women's Health Centre of British Columbia, British Columbia, Canada.
Carey Matsuba
Affiliation:
Department of Pediatrics, University of British Columbia, British Columbia, Canada.
Elaine Orrbine
Affiliation:
Child and Youth Clinical Trials Network, Children's Hospital of Eastern Ontario Research Institute, Ontario, Canada.
Ba' Pham
Affiliation:
Children's Hospital of Eastern Ontario Research Institute, Ontario, Canada.
Sharon Whiting
Affiliation:
Department of Pediatrics, Division of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Get access

Abstract

To determine the effect of intravenous porcine secretin on autistic behaviours in children aged 2 to 7 years, the effects of secretin on (1) performance on a standardized language measure, and (2) autistic behaviours, as rated by parents and child development professionals was examined. Employing a randomized, double-blind, placebo-controlled design, 95 participants were assigned to one of two groups and administered a single dose of either secretin or placebo. A follow-up assessment was conducted 3 weeks after the injection. No significant differences in language or autistic behaviour measures were observed at the 3-week follow-up between the groups. Also, there was no significant difference in the proportion of individuals who improved by [ges ] 6 points on the language measure at follow-up. This study showed no significant effects of secretin on children with autism. Our results are consistent with a systematic review of randomized controlled trials evaluating the effect of secretin in children with autism.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 42 , Issue 12 , December 2000 , pp. 796 - 802
Copyright
© 2000 Mac Keith Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)