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V.—Some Observations on the Coagulation of the Blood

Published online by Cambridge University Press:  17 January 2013

John Davy
Affiliation:
Lond. and Edin.

Extract

In a recent work of an elaborate kind, displaying much ability, its author, Dr Richardson, has endeavoured to prove that the cause of the coagulation of the blood is of a chemical nature, and referable to the escape of a volatile matter, and that the volatile matter is ammonia.

It is not my intention at present to consider the various circumstances which he brings forward in favour of his conclusion. I shall restrict myself to a few observations which I have made, the results chiefly of trials instituted for the purpose of testing his speculations, and of satisfying myself, if possible, on the subject.

Type
Transactions
Copyright
Copyright © Royal Society of Edinburgh 1861

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References

page 51 note * The “Cause of the Coagulation of the Blood,” being the Astley Cooper Prize Essay for 1856, with Additional Observations and Experiments, &c. By B. W. Richardson, M.D, 8vo, London, 1858.

page 51 note * The capacity was greater; it held 298 grains of water.

page 53 note * See my “Researches Physiological and Anatomical,” vol. ii., p. 105, for instances.

page 54 note * Plunged into water of 210°, the white of egg coagulated, though a large proportion of the ammonia still remained in the solution. A mixture of white of egg and bicarbonate of potash similarly treated, an effervescence occurred, and a coagulation formed. This I notice to show that the presence of an alkali does not prevent the coagulation of albumen by heat, leading to the inference that its liquid state is not owing to the little alkali which it contains. I may mention another fact having the same bearing. A portion of milk, to which a little ammonia had been added was put by to see how long it would keep sweet, air being excluded, the bottle being filled and well secured with a glass stopper. It was long forgotten; after two or three years it attracted attention. Now it wis found that a film of black matter, which proved to be sulphuret of iron, was formed covering the whole of the inside of the vial; that the milk had acquired a brown hue, the cream on its surface remaining almost colourless, and that though it was alkaline, yet a small portion of curd had formed

page 56 note * The fibrin, after solution, appears to be altered in its properties: obtained by evaporation (as the ammonia is expelled it forms as a pellicle) though still soluble in a slight degree in the volatile alkali, it is not rendered viscid, and, in consequence, there is no obstacle in the way of its filtration.

page 56 note † See “Researches Anatomical and Physiological,” vol. ii., p. 343.

page 56 note ‡ “Report on the First Eighteen Months of the Fourth Yellow Fever Epidemic of British Guiana,” p. 37.