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An intra-oral inoculation technique for the production of experimental pneumonia in mice

Published online by Cambridge University Press:  15 May 2009

S. S. Epstein  and
G. D. Breach
S. S. Epstein
Affiliation:
From the Department of Pathology, Institute of Laryngology and Otology, London
G. D. Breach
Affiliation:
From the Department of Pathology, Institute of Laryngology and Otology, London
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Techniques for the production of experimental pneumonia are briefly reviewed. A new method of intra-oral inoculation in the anaesthetized mouse is described and its advantages with particular reference to the danger of aerial contamination and facility of technique discussed. An application of this method to virulence studies is indicated and other possible applications suggested.

The author would like to express gratitude to Dr I. Friedmann for having made this work possible and for his advice and help at all stages. He would also like to thank the late Sir E. L. Kennaway, Dr F. Fulton and Dr D. A. Osborn for helpful suggestions, Prof. E. T. C. Spooner for the kind loan of the Bourdillon apparatus, Dr S. T. Cowan for an N.C.T.C. strain of Klebsiella, Mr P. Payne for statistical advice and Mr D. Connolly for the photomicrograph.

Type
Research Article
Information
Journal of Hygiene , Volume 56 , Issue 1 , March 1958 , pp. 73 - 79
Copyright
Copyright © Cambridge University Press 1958

References

REFERENCES

Andrewes, C. H., Laidlaw, P. P. & Smith, W. (1934). Lancet. ii, 859.CrossRefGoogle Scholar
Blake, F. G. & Cecil, R. L. (1920). J. exp. Med. 31, 403.CrossRefGoogle Scholar
Burnet, F. M. & Timmins, C. (1937). Brit. J. exp. Path. 18, 83.Google Scholar
Gamaleia, M. N. (1888). Ann. inst. Pasteur, 2, 440.Google Scholar
Gardner, L. U. (1932). J. industr. Hyg. 14, 18.Google Scholar
Gunn, F. D. & Nungester, W. J. (1936). Arch. Path. (Lab. Med.) 21, 813.Google Scholar
Hamburger, M. & Robertson, O. H. (1940). J. exp. Med. 72, 261.CrossRefGoogle Scholar
Henderson, D. W. (1952). J. Hyg., Camb., 50, 53.CrossRefGoogle Scholar
Hoyle, L. (1935). J. Path. Bact. 41, 163.CrossRefGoogle Scholar
Hoyle, L. & Orr, J. W. (1945). J. Path. Bact. 57, 441.CrossRefGoogle Scholar
Jourdonais, L. F. & Nungester, W. J. (1935). Science, 81, 74.CrossRefGoogle Scholar
Kettle, E. H. & Hilton, R. (1932). Lancet, i, 1190.CrossRefGoogle Scholar
Neufeld, F. & Kuhn, H. (1934). Z. Hyg. InfektKr. 116, 697.CrossRefGoogle Scholar
Reed, L. J. & Muench, J. (1938). Amer. J. Hyg. 27, 493.Google Scholar
Report (1946). Chemotherapeutic and other studies of typhus. Spec. Rep. Ser. med. Res. Coun., Lond., no. 255. H.M.S.O. London.Google Scholar
Rudd, G. V. & Burnet, F. M. (1941). Aust. J. exp. Biol. med. Sci. 19, 33.CrossRefGoogle Scholar
Smith, W., Andrewes, C. H. & Laidlaw, P. P. (1933). Lancet, ii, 66.CrossRefGoogle Scholar
Standfast, A. F. B. (1951). J. gen. Microbiol. 5, 250.CrossRefGoogle Scholar
Stillman, E. G. & Branch, A. (1924). J. exp. Med. 40, 743.Google Scholar
Stuppy, G. W., Cannon, P. R. & Falk, I. S. (1929). Proc. Soc. exp. Biol., N.Y., 26, 314.CrossRefGoogle Scholar
van den Ende, M. (1943). J. Hyg., Camb., 43, 189.CrossRefGoogle Scholar
van den Ende, M. & Lush, D. (1943). J. Path. Bact. 55, 81.CrossRefGoogle Scholar
Wadsworth, W. F. (1904). Amer. J. med. Sci. 127, 851.CrossRefGoogle Scholar
Wells, W. F. (1948). Amer. J. Hyg. 47, 1.Google Scholar