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An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species

Published online by Cambridge University Press:  01 August 1999

A. VOS
Affiliation:
IDT (Impfstoffwerk Dessau-Tornau GmbH), PSF 214, 06855 Rosslau, Germany
A. NEUBERT
Affiliation:
IDT (Impfstoffwerk Dessau-Tornau GmbH), PSF 214, 06855 Rosslau, Germany
O. AYLAN
Affiliation:
Etlik Central Veterinary Research and Control Institute, Etlik – Ankara 06020, Turkey
P. SCHUSTER
Affiliation:
IDT (Impfstoffwerk Dessau-Tornau GmbH), PSF 214, 06855 Rosslau, Germany
E. POMMERENING
Affiliation:
IDT (Impfstoffwerk Dessau-Tornau GmbH), PSF 214, 06855 Rosslau, Germany
T. MÜLLER
Affiliation:
Federal Research Centre for Virus Diseases of Animals, 16868 Wusterhausen, Germany
D. CHAI CHIVATSI
Affiliation:
Institute of Primate Research, PO Box 24481, Nairobi, Kenya
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Abstract

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SAD B19 is an attenuated vaccine virus for oral vaccination of carnivores against rabies. The safety of SAD B19 was investigated in 16 animal species by different routes of administration. During the observation period all animals given the vaccine virus, irrespective of the route of administration, did not show any clinical signs of rabies, with the exception of certain rodent species. In these animals a low residual pathogenicity was observed, however transmission of the vaccine virus to control animals was not demonstrable. No vaccine virus could be detected in the saliva of the six mammal species examined. Furthermore, the genetical stability was shown for SAD B19 through passaging in neural tissue of dogs, foxes and mice. From the results presented here on innocuity and stability, it can be concluded that SAD B19 rabies vaccine is suitable for oral vaccination campaigns for carnivores against rabies.

Type
Research Article
Copyright
© 1999 Cambridge University Press