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Antibody response in pig nasal fluid and serum following foot-and-mouth disease infection or vaccination

Published online by Cambridge University Press:  19 October 2009

M. J. Francis  and
L. Black
M. J. Francis
Affiliation:
Wellcome Biotechnology Limited, Wellcome FMD Vaccine Laboratory, Ash Road, Pirbright, Woking, Surrey
L. Black
Affiliation:
Wellcome Biotechnology Limited, Wellcome FMD Vaccine Laboratory, Ash Road, Pirbright, Woking, Surrey
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Summary

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Nasal fluid and serum collected from pigs after exposure to live foot and mouth disease (FMD) virus or injection of single oil emulsion (w/o) or double oil emulsion (w/o/w) vaccines were examined for FMD neutralizing activity. After virus exposure the response profiles of serum and nasal mucus were similar to one another. In both, neutralizing activity rose to a peak at one to two weeks after exposure and then subsided slowly. After vaccination with either the w/o or w/o/w preparations a neutralizing response was demonstrable in the serum three to seven days after the first injection, and this was boosted by revaccinations 56 and 117 days later. The neutralizing activity was also detectable in nasal fluid seven days after the first vaccination, but subsequent revaccinations 56 and 117 days later provoked neutralizing titres which were no greater than those observed after the initial vaccination.

Type
Research Article
Information
Journal of Hygiene , Volume 91 , Issue 2 , October 1983 , pp. 329 - 334
Copyright
Copyright © Cambridge University Press 1983

References

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