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Antimicrobial sensitivity patterns of hospital and non-hospital strains of Staphylococcus aureus isolated from nasal carriers

Published online by Cambridge University Press:  25 March 2010

M. O. Paul ,
D. A. Aderibigbe ,
C. Z. Sule  and
A. Lamikanra
M. O. Paul
Affiliation:
Unit of Medical Microbiology, Faculty of Health Sciences, University of Ife, Ile-Ife, Nigeria
D. A. Aderibigbe
Affiliation:
Unit of Medical Microbiology, Faculty of Health Sciences, University of Ife, Ile-Ife, Nigeria
C. Z. Sule
Affiliation:
Unit of Medical Microbiology, Faculty of Health Sciences, University of Ife, Ile-Ife, Nigeria
A. Lamikanra
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, University of Ife, Ile-Ife, Nigeria
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Summary

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The nasal carriage rate of Staphylococcus aureus was significantly higher in hospitalized persons (children, adult females and staff) − 53·8%, – than in similar persons at a local clinic − 29·8% (P < 0·001) – in Ile-Ife, Nigeria. However, unlike studies carried out elsewhere, a higher proportion of S. aureus strains obtained from persons at the clinic were resistant to commonly used antimicrobial agents than were strains isolated in the hospital. This has been attributed to the ease at which these drugs can be obtained by the general population and used unsupervised and indiscriminately. Methicillin was the most effective antimicrobial agent against pathogenic staphylococci (2·2% resistance), followed by erythromycin (16·5% resistance), co-trimaxozole (28·0 % resistance), chloramphenicol (76·9 % resistance), tetracycline (78·6% resistance) and penicillin and ampicillin (97·8% resistance). The widespread resistance of S. aureus to penicillin and ampicillin (and other antimicrobial agents) is of clinical significance in the treatment of post-operative infections, since carriers are reportedly more prone to such infections than are non-carriers.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 2 , October 1982 , pp. 253 - 260
Copyright
Copyright © Cambridge University Press 1982

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