Hostname: page-component-84b7d79bbc-rnpqb Total loading time: 0 Render date: 2024-07-26T11:26:38.489Z Has data issue: false hasContentIssue false
  • English
  • Français

Biophysical and immunological studies on the differential effect of guanidine hydrochloride on type A and type B influenza viruses

Published online by Cambridge University Press:  15 May 2009

Tam. S. David-West
Tam. S. David-West
Affiliation:
Department of Bacteriology, University College Hospital Medical School, London W.C.I, England
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Guanidine hydrochloride selectively inactivated both the biological activity and the immunogenicity of the haemagglutinin of influenza A/X-7 (H0N2). The residual neuraminidase was fully active biologically and immunologically. The reverse was observed with influenza B/ROB; with this virus the haemagglutinin was resistant, and was immunogenic; while the neuraminidase was selectively inactivated, and was not immunogenic.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 1 , February 1974 , pp. 31 - 39
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Allan, W. H., Madeley, C. R. & Kendal, A. P. (1971). Studies with avian influenza viruses: Cross protection experiments in chickens. Journal of General Virology 12, 79–84.CrossRefGoogle ScholarPubMed
Aminoff, D. (1961). Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochemical Journal 81, 384–92.CrossRefGoogle ScholarPubMed
Chakraverty, P. (1972). Antigenic relationships between the neuraminidases of influenza B viruses. Bulletin of the World Health Organization 46, 473–6.Google Scholar
Coleman, M. T., Dowdle, W. R., Pereira, H. G., Schild, G. C & Chang, W. K. (1968). The Hong Kong/68 influenza A2 variant. Lancet ii, 1384—6.CrossRefGoogle Scholar
David-West, T. S. (1973). A new genetic marker for influenza virus subunits. Archiv für die gesamte Virusforschung 41, 143–6.CrossRefGoogle ScholarPubMed
David-West, T. S. & Belyavin, G. (1973). Differential effect of guanidine hydrochloride and heat on the haemagglutinin and neuraminidase of influenza viruses. Archiv für die gesamte Virusforschung (In the press).CrossRefGoogle Scholar
Kendal, A. P., Biddle, F. & Belyavin, G. (1968). Influenza virus neuraminidase and the viral surface. Biochimica Biophysica Acta 165, 419–31.Google Scholar
Kilbourne, E. D., Lief, F. S., Schulman, J. L., Jahiel, R. I. & Laver, W. G. (1967). Antigenic hybrids of influenza viruses and their implications. Perspectives in Virology 5, 87–106.Google Scholar
Kilbourne, E. D., Laver, W. G., Schulman, J. L. & Webster, R. G. (1968). Antiviral activity of antiserum specific for an influenza virus neuraminidase. Journal of Virology 2, 281–8.CrossRefGoogle ScholarPubMed
Laver, W. G. & Kilbourne, E. D. (1966). Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology 30, 493–501.CrossRefGoogle Scholar
Laverb, W. G. & Valentine, R. C. (1969). Morphology of the isolated haemagglutinin and neuraminidase subunits of influenza virus. Virology 38, 105–19.CrossRefGoogle Scholar
Murphy, B. R., Julius, A. K. & Chanock, R. M. (1972). Association of serum anti-neuraminidase antibody with resistance to influenza in man. New England Journal of Medicine 286, 1329–32.CrossRefGoogle ScholarPubMed
Schulman, J. L., Khakpour, M. & Kilbourne, E. D. (1968). Protective effects of specific immunity to viral neuraminidase on influenza virus infection in mice. Journal of Virology 2, 778–86.CrossRefGoogle Scholar
Schulman, J. L. (1969). The role of antineuraminidase antibody in immunity to influenza virus infection. Bulletin of the World Health Organization 41, 647–50.Google ScholarPubMed
Schulman, J. L. & Kilbourne, E. D. (1969). Independent variation in nature of haemagglutinin and neuraminidase antigens of influenza virus: distinctiveness of haemagglutinin antigen of Hong Kong/68 virus. Proceedings of the National Academy of Sciences of the U.S.A. 63, 326–33.CrossRefGoogle ScholarPubMed
Slepushkin, A. N., Schild, G. C., Beare, A. S., Chinn, S. & Tyrrell, D. A. J. (1971). Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines. Journal of Hygiene 69, 571–8.Google ScholarPubMed
WHO Group on the Nomenclature of Influenza Viruses (1971). A revised system of nomenclature for influenza viruses. Bulletin of the World Health Organization 45, 119–24.Google Scholar