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Complement fixation and neutralization RS antibodies in maternal and neonatal sera

Published online by Cambridge University Press:  15 May 2009

R. A. Heijtink
Affiliation:
Department of Virology, Erasmus University Rotterdam, Rotterdam, The Netherlands
G. Backx
Affiliation:
Department of Virology, Erasmus University Rotterdam, Rotterdam, The Netherlands
J. M. Van Der Horst
Affiliation:
Department of Virology, Erasmus University Rotterdam, Rotterdam, The Netherlands
N. Masurel
Affiliation:
Department of Virology, Erasmus University Rotterdam, Rotterdam, The Netherlands
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Summary

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RSV complement fixation antibodies were established in 200 paired maternal and cord blood sera. Geometric mean titres in cord sera were significantly higher than in maternal sera. The differences did not depend on the virus strain used. Half of the paired sera (taken at random) were also submitted to microneutralization tests. No differences were found between geometric mean titres in maternal and cord sera.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Ana, P. P. Sta.Arrobio, J. O., Kim, H. W., Brandt, C. D., Chanock, R. M. & Parrott, R. H. (1970). Serum complement in acute bronchiolitis. Proceedings of the Society for Experimental Biology and Medicine 134, 499.CrossRefGoogle ScholarPubMed
Beem, M., Egerer, R. & Anderson, J. (1964). Respiratory syncytial virus neutralizing antibodies in persons residing in Chicago, Illinois. Pediatrics 34, 761.CrossRefGoogle ScholarPubMed
BrouwerR., de R., deGroot, I. G. M. & Verheij, F. B. M. (1974). Comparison of maternal and cord serum titres for measles and for rubella antibodies. Archiv für die gesamte Virusforschung 44, 237.CrossRefGoogle ScholarPubMed
Chanock, R. M., Kapikian, A. Z., Mills, J., Kim, H. W. & Parrott, R. H. (1970). Influence of immunological factors in respiratory syncytial virus disease. Archives of Environmental Health 21, 347.CrossRefGoogle ScholarPubMed
Chanock, R. M., Parrott, R. H., Kapikian, A. Z., Kim, H. W. & Brandt, C. D. (1968). Possible role of immunological factors in pathogenesis of RS virus lower respiratory tract disease. In Perspectives in Virology (ed. M., Pollard). New York: Academic Press 6, 125.Google Scholar
Coates, H. V., Alling, D. W. & Chanock, R. M. (1966). An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test. American Journal of Epidemiology 83, 299.CrossRefGoogle ScholarPubMed
Field, P. R. & Murphy, A. M. (1972). The role of specific IgM globulin estimations in the diagnosis of acquired rubella. Medical Journal of Australia ii, 1244.CrossRefGoogle Scholar
Fulginiti, V. A., Sieber, O. F., Claman, H. N. & Merrill, D. (1966). Serum immunoglobulin measurement during the first year of life and in immunoglobulin deficiency states. Journal of Pediatrics 68, 723.CrossRefGoogle ScholarPubMed
Gardner, P. S., McQuillin, J. & Court, S. D. M. (1970). Speculation on pathogenesis in death from respiratory syncytial virus infection. British Medical Journal i, 327.CrossRefGoogle Scholar
Gell, P. H. G. & Coombs, R. A. A. (eds.) (1968). Clinical Aspects of Immunology, 2nd ed. Oxford: Blackwell.Google Scholar
Gitlin, D., Kumate, J., Urrusti, J. & Morales, J. (1964). The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. Journal of Clinical Investigation 43, 1938.CrossRefGoogle ScholarPubMed
Grist, N. R., Ross, C. A. & Bell, E. J. (1974). Diagnostic Methods in Clinical Virology. Oxford: Blackwell.Google Scholar
Kim, H. W., Leikin, S. L., Arrobio, J., Brandt, C. D., Chanock, R. M. & Parrott, R. H. (1976). Cell-mediated immunity to respiratory syncytial virus induced by inactivated vaccine or by infection. Pediatric Research 10, 75.CrossRefGoogle ScholarPubMed
Kohler, P. F. & Farr, R. S. (1966). Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport. Nature, London 210, 1070.CrossRefGoogle ScholarPubMed
Lennette, E. H. & Schmidt, N. J. (1969). Diagnostic Procedures for Viral and Rickettsial Infections. New York: American Public Health Association.Google Scholar
Longworth, L. G., Curtis, R. M. & Pembroke, R. H. (1945). The electrophoretic analysis of maternal and fetal plasmas and sera. Journal of Clinical Investigation 26, 46.CrossRefGoogle Scholar
Mäntyjärvi, R., Hirvonen, T. & Toivanen, P. (1970). Maternal antibodies in human neonatal sera. Immunology 18, 449.Google ScholarPubMed
MasurelN., de N., deBruijne, J. I., Beuningh, H. & Schouten, H. J. A. (1977). Influenza A and influenza B antibodies in maternal and neonatal sera. (In preparation.)Google Scholar
Michaux, J. L., Heremans, J. F. & Hitzig, W. H. (1966). Immunoglobulin levels in cordblood serum of Negroes and Caucasians. Tropical and Geographical Medicine 18, 10.Google ScholarPubMed
Parrott, R. H., Kim, H. W., Brandt, C. D. & Chanock, R. M. (1974). Respiratory syncytial virus in infants and children. Preventive Medicine 3, 473.CrossRefGoogle ScholarPubMed
Parrott, R. H., Kim, H. W., Brandt, C. D. & Chanock, R. M. (1975). Potential of attenuated respiratory synoytial virus vaccine for infants and children. In Developments in Biological Standardization. Basel: Karger. 28, 389.Google Scholar
Prince, G. A. & Porter, D. D. (1976). The pathogenesis of respiratory syncytial virus infection in infant ferrets. American Journal of Pathology 82, 339.Google ScholarPubMed
Pyhälä, R. & Kleemola, M. (1976). The value of complement fixation and haemagglutination inhibition test in the diagnosis of influenza A. Acta virologica 20, 66.Google ScholarPubMed
Siegel, S. (1956). Nonparametric Statistics for the Behavioral Sciences, p. 312. New York: McGraw-Hill.Google Scholar
Stelzner, A., Brunnemann, H., Umland, T., Muller, W., Klinger, G. & Seewald, H.-J. (1973). Untersuchungen über komplementbindende RS-Virus-Antikorper. Zeitschrift für Erkrankungen der Atmungsorgane 138, 279.Google Scholar
Toivanen, P., Mäntyjärvi, R. & Hirvonen, T. (1968). Maternal antibodies in human foetal sera at different stages of gestation. Immunology 15, 395.Google ScholarPubMed