Hostname: page-component-84b7d79bbc-l82ql Total loading time: 0 Render date: 2024-07-25T14:56:27.172Z Has data issue: false hasContentIssue false
  • English
  • Français

Different seroprevalences of antibodies against Neisseria meningitidis serogroup A and Haemophilus influenzae type b in Sudanese and Swedish children

Published online by Cambridge University Press:  19 October 2009

M. A. M. Salih ,
H. Fredlund ,
S. Hugosson ,
L. Bodin  and
P. Olcén
M. A. M. Salih
Affiliation:
Department of Paediatrics, Faculty of Medicine, University of Khartoum, Sudan
H. Fredlund*
Affiliation:
Department of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden
S. Hugosson
Affiliation:
Otorhinolaryngology, Örebro Medical Center Hospital, Örebro, Sweden
L. Bodin
Affiliation:
Occupational Medicine, Örebro Medical Center Hospital, Örebro, Sweden
P. Olcén
Affiliation:
Department of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden
*
*Hans Fredlund, Department of Clinical Microbiology and Immunology, Örebo Medical Center Hospital, S-701 85 Örebro, Sweden.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Sampling of sera from 202 Sudanese and 124 Swedish children 1–14 years of age was conducted at the end of the 1980s presenting an opportunity to compare the seroprevalence of anti-Neisseria meningitidis (MC) serogroup A antibodies in an area immediately before outbreak of an epidemic (Sudan 1988) with a low endemic area (Sweden). An ELISA antibody assay was developed for detection of antibodies against capsular polysaccharide of MC serogroup A and Haemophilus influenzae type b (Hib). Serum antibody against MC serogroup A was found significantly more frequently in Sudanese than in Swedish children. This indicates that factors other than herd immunity, as measured by serum antibodies against MC serogroup A polysaccharide, are important for avoidance of an MC serogroup A epidemic. The seroprevalence of Hib antibodies was, in contrast, significantly higher in Swedish than in Sudanese children, especially for 5–9-year-old children. A possible explanation may be the different systems of day-care of children in the two countries.

Type
Research Article
Information
Epidemiology & Infection , Volume 110 , Issue 2 , April 1993 , pp. 307 - 316
Copyright
Copyright © Cambridge University Press 1993

References

REFERENCES

1.Greenwood, BM, Blakebrough, IS, Bradley, AK, Wall, SWhittle, HC.Meningoeoecal disease and season in sub-Saharan Africa. Lancet 1984; i: 1339–42.Google Scholar
2.Noah, ND.Epidemiology of bacterial meningitis. UK and USA. In: Williams, JD, Burnie, J eds. Bacterial meningitis. London: Academic Press. 1987: 93–115.Google Scholar
3.Sell, SHW.Haemophilus influenzae type b meningitis: manifestations and long-term sequelae. Pediatr Infect Dis J 1987: 6: 775–8.Google ScholarPubMed
4.Smith, AL.Neurologic sequelae of meningitis. N Engl J Med 1988; 319: 1012–14.Google ScholarPubMed
5.Greenwood, BM.The epidemiology of acute bacterial meningitis in tropical Africa. In: Williams, JD, Burnie, J, eds. Bacterial meningitis. London: Academic Press. 1987: 61–91.Google Scholar
6.Broome, CV, Rugh, MA, Yada, AA et al. . Epidemic group C meningococcal meningitis in Upper Volta, 1979. Bull WHO 1983; 61: 325–30.Google Scholar
7.Olcén, P, Barr, J, Kjellander, J.Meningitis and baeteriemia due to Neisseria meningitidis: clinical and laboratory findings in 69 cases from Örebro county, 1965 to 1977. Scand J Infect Dis 1979; 11: 111–19.Google ScholarPubMed
8.Bövre, K.Meningococcal disease in Norway. Antonie van Leeuwenhoek J Microbiol 1986: 52: 249–50.Google Scholar
9.Salwén, KM, Vikerfors, T, Olcén, P.Increased incidence of childhood bacterial meningitis. A 25-year study in a defined population in Sweden. Scand J Infect Dis 1987: 19: 1–11.Google Scholar
10.Salih, MAM, El Hag, AI, Ahmed, HS. et al. Endemic bacterial meningitis in Sudanese children: aetiology, clinical findings, treatment and short term outcome. Ann Trop Paediatr 1990; 10: 203–10.Google ScholarPubMed
11.Anonymous. Meningococcal meningitis. Wkly Epidem Rec 1976: 51: 333–7.Google Scholar
12.Peltola, H.Meningococcal disease: still with us. Rev Infect Dis 1983; 5: 71–91.Google ScholarPubMed
13.Lapeyssonie, L.La méningite cérébro-spinale en Afrique. Bull WHO 1963: 28 (suppl): 3–114.Google Scholar
14.Salih, MAM, Danielsson, D, Bäckman, A, Caugant, D, Achtman, M, Olcén, P.Characterization of epidemic and non-epidemic Neisseria meningitidis serogroup A strains from Sudan and Sweden. J Clin Microbiol 1990; 28: 1711–19.Google Scholar
15.Danielsson, D, Olcén, P.Epidemiology of infections with pathogenic Neisseria in Sweden. In: Poolman, JT, ed. Gonococci and meningococci. Dordrecht. The Netherlands: Kluwer Academic Publishers. 1988: 81–8.Google Scholar
16.Takala, AK, Eskola, J, Peltola, H, Mäkelä, PH.Epidemiology of invasive H. influenzae type b disease among children in Finland before vaccination with H. influenzae type b conjugate vaccine. Pediatr Infect Dis J 1989: 8: 297–302.Google Scholar
17.Gilbert, G, Clements, D, Broughton, S.H. influenzae type b infections in Victoria. Australia. 1985 to 1987. Pediatr Infect Dis J 1990; 9: 252–7.Google ScholarPubMed
18.Wilfert, C.Epidemiology of H influenzae type b infections. Pediatrics 1990; 85: 631–5.Google Scholar
19.van Alphen, L, Bijmer, H.Molecular epidemiology of H. influenzae type b. Pediatrics 1990: 85: 636–41.Google Scholar
20.Granoff, D, Basden, M.H. influenzae infections in Fresno county. California: a prospective study of the effects of age, race and contact with a case on incidence of disease. J Infect Dis 1980; 141: 40–6.Google ScholarPubMed
21.Fredlund, H, Selldén, H, Danielsson, D, Olcén, P.Early development in healthy children of serum opsonins against non-pathogenic Neisseria meningitidis. APMIS 1992; 100: 449–54.Google Scholar
22.Amemiya, T.Qualitative response models: a survey. J Econ Lit 1981; 19: 1483–1536.Google Scholar
23.Hall, BH, Cummins, C, Schnake, R. Time Series Processor, Version 4.2. TSP International, Palo Alto, 1991.Google Scholar
24.Griffiss, JMcL.Bactericidal activity of meningococcal antisera: blocking by IgA of lytie antibody in human convalescent sera. J Immunol 1975; 114: 1779–84.Google Scholar
25.Salih, MAM, Ahmed, HS, Karrar, ZA et al. Features of a large epidemic of group A meningococcal meningitis in Khartoum, Sudan in 1988. Scand J Infect Dis 1990; 22: 101–70.Google Scholar
26.Erwa, HH, Haseeb, MA, Idris, AA, Lapeyssonnie, L, Sanborn, WR, Sippel, JE.A serogroup A meningococcal polysaccharide vaccine: studies in Sudan to combat cerebrospinal meningitis caused by Neisseria meningitidis group A. Bull WHO 1973; 49: 301–5.Google ScholarPubMed
27.Peltola, H.Group A meningococcal polysaccharide vaccine and course of the group A meningococcal epidemic in Finland. Scand J Infect Dis 1978; 10: 41–4.Google Scholar
28.Galazka, A.Meningococcal disease and its control with meningococcal polysaccharide vaccine. Bull WHO 1982; 60: 1–7.Google Scholar
29.Trollfors, B, Claesson, B, Strangert, K, Taranger, J.H. influenzae meningitis in Sweden 1981–83. Arch Dis Child 1987; 62: 1220–3.Google Scholar
30.Trollfors, B, Nylén, O, Strangert, K.Acute epiglottitis in children and adults in Sweden 1981–83. Arch Dis Child 1990; 65: 491–4.Google Scholar