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The effect of sex and age on the response to warfarin in a non-inbred strain of mice*

Published online by Cambridge University Press:  15 May 2009

F. P. Rowe  and
R. Redfern
F. P. Rowe
Affiliation:
Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Tolworth, Surbiton, Surrey
R. Redfern
Affiliation:
Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Tolworth, Surbiton, Surrey
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1. A marked sex variation in susceptibility to warfarin was found in 6-month old L.A.C. Grey mice, males being more susceptible than females. No sex difference in response was evident in young mice 6 weeks old.

2. Susceptibility to warfarin poisoning increased markedly with age in males but not in females.

3. No significant increase in mortality following warfarin poisoning occurred in adult female mice given methyl testosterone.

Type
Research Article
Information
Journal of Hygiene , Volume 65 , Issue 1 , March 1967 , pp. 55 - 60
Copyright
Copyright © Cambridge University Press 1967

References

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