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Epidemiological studies of Epstein–Barr herpesvirus infection in Western Australia

Published online by Cambridge University Press:  15 May 2009

P. K. Lai ,
E. M. Mackay-Scollay  and
M. P. Alpers
P. K. Lai
Affiliation:
Division of Microbiology, State Health Laboratory Services, Western Australia
E. M. Mackay-Scollay
Affiliation:
Division of Microbiology, State Health Laboratory Services, Western Australia
M. P. Alpers
Affiliation:
Department of Microbiology, University of Western Australia, Perth Medical Centre, Shenton Park 6008, Western Australia
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Summary

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In a study on a Caucasian population in Western Australia the prevalence of antibodies to Epstein–Barr virus (EBV) was 41% in the 9- to 10-year age group, 80% in the 16 to 19-year age group and 92% in young adults. The age-specific annual seroconversion rates indicated two peaks of primary EBV infection in the population studied – one under 5 years of age and the other at adolescence. The geometric mean titre rose with age, from 23 at 5–6 years to 53 at 36–40 years.

It was shown that in 73 families studied there was evidence of probable spread of EBV infection among siblings, particularly between those of the same sex.

Serological study of patients with infectious mononucleosis indicated that 100% of those examined had antibody to EBV and the geometric mean titre was elevated to 210. Rising titres and seroconversion was demonstrated in these patients together with successful establishment of EBV-carrying cell lines from the peripheral blood in two-thirds of the cases.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 3 , June 1975 , pp. 329 - 337
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Curnow, D. H., Cullen, K. J., McCall, M., Stenhouse, N. S. & Welborn, T. A. (1969). Health and disease in a rural community – a Western Australian study. Australian Journal of Science 31, 281–5.Google Scholar
Epstein, M. A., Achong, B. G. & Barr, Y. M. (1964). Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet i, 702–3.CrossRefGoogle Scholar
Evans, A. S. & Niederman, J. C. (1972). Epidemiology of infectious monocucleosis: a review. In Oncogenesis and Herpesviruses (ed. Biggs, P. M., De-Thé, G. and Payne, L. N.), pp. 351–6. Lyon: International Agency for Research on Cancer.Google Scholar
Golubjatnikov, R., Allen, V. D., Steadman, M., Del Pilar Olmos Blancarte, M. & Inhorn, S. L. (1973). Prevalence of antibodies to Epstein–Barr virus, cytomegalovirus and toxoplasma in a Mexican highland community. American Journal of Epidemiology 97, 116–24.CrossRefGoogle Scholar
Henle, G. & Henle, W. (1966). Immunofluorescence in cells derived from Burkitt's lymphoma. Journal of Bacteriology 91, 1248–56.CrossRefGoogle ScholarPubMed
Henle, G. & Henle, W. (1967). Immunofluorescence, interference, and complementfixation technics in the detection of the herpes-type virus in Burkitt tumor cell lines. Cancer Research 27, 2442–6.Google Scholar
Henle, G. & Henle, W. (1970). Observations on childhood infections with the Epstein-Barr virus. Journal of Infectious Diseases 121, 303–10.CrossRefGoogle ScholarPubMed
Hinuma, Y., Ohta-Hatano, R., Suto, T. & Numazaki, Y. (1969). High incidence of Japanese infants with antibody to herpes-type virus associated with cultured Burkitt lymphoma cells. Japanese Journal of Microbiology 13, 309–11.CrossRefGoogle ScholarPubMed
Hubble, M. P., Lai, P. K., Mackay-Scollay, E. M. & Alpers, M. P. (1974). Epidemiology of infectious mononucleosis in Western Australia – a retrospective hospital survey 1966–1973. Medical Journal of Australia 2, 863–6.CrossRefGoogle Scholar
Lai, P. K., Mackay-Scollay, E. M. & Alpers, M. P. (1973 a). Synthesis of virus-capsid antigen (VCA) enhanced by ultraviolet irradiation of a lymphoblastoid cell line carrying Epstein-Barr virus. Journal of General Virology 21, 135–43.CrossRefGoogle ScholarPubMed
Lai, P. K., Papadimitriou, J. M., Kennett, D. W. G., Mackay-Scollay, E. M. & Alpers, M. P. (1973 b). A lymphoblastoid cell line derived from cells of myeloid leukaemia by infection with the Epstein–Barr herpesvirus. Cytobios 8, 125–38.Google Scholar
Leading Article (1974). Busselton revisited. Medical Journal of Australia 2, 31–2.CrossRefGoogle Scholar
Miller, G., Niederman, J. C. & Andrews, L. L. (1973). Prolonged oropharyngeal excretion of Epstein–Barr virus after infectious mononucleosis. New England Journal of Medicine 288, 229–32.CrossRefGoogle ScholarPubMed
Niederman, J. C., Evans, A. S., Subrahmanyan, L. & McCollum, R. W. (1970). Prevalence, incidence and persistence of EB virus antibody in young adults. New England Journal of Medicine 282, 361–5.CrossRefGoogle ScholarPubMed
Pope, J. H. (1967). Establishment of a cell line from peripheral leukocytes in infectious mononucleosis. Nature, London 216, 810–1.CrossRefGoogle Scholar
Pope, J. H. (1968). Establishment of a cell line from Australian leukaemic patients: presence of a herpes-like virus. Australian Journal of Experimental Biology and Medical Science 46, 643–5.CrossRefGoogle Scholar
Porter, D. D., Wimberley, I. & Benyesh-Melnick, M. (1969). Prevalence of antibodies to EB virus and other herpesviruses. Journal of the American Medical Association 208, 1675–9.CrossRefGoogle ScholarPubMed
Shope, T. & Miller, G. (1973). Heterophil responses in squirrel monkeys inoculated with virus-transformed autologous leukocytes. Journal of Experimental Medicine 137, 140–7.CrossRefGoogle Scholar
Werner, J., Pinto, C. A., Haff, R. F., Henle, W. & Henle, G. (1972). Response of gibbons to inoculation of Epstein–Barr virus. Journal of Infectious Diseases 126, 678–81.CrossRefGoogle ScholarPubMed