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Evolutionary changes in myxoma virus in Britain: An examination of 222 in naturally occurring strains obtained from 80 counties during the period October–November 1962

Published online by Cambridge University Press:  15 May 2009

Frank Fenner  and
Paul J. Chapple
Frank Fenner
Affiliation:
Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T., Australia
Paul J. Chapple
Affiliation:
Ministry of Agriculture, Fisheries and Food, Infestation Control Laboratory, Worplesdon, Surrey, England
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Samples of lesions containing viable myxoma virus were collected from 222 infected wild rabbits captured in 80 counties of Britain during October–November 1962. They were dispatched by air to Australia and passaged once in domestic rabbits before being tested for their virulence by the intradermal inoculation of groups of six laboratory rabbits with small doses of virus.

The results showed that a wide range of viruses of differing properties now coexist in Britain. Their virulence ranges from very high (99 % lethal) to low (about 50 %), but the majority of strains fall into the grade III virulence group, with estimated case mortality rates varying between 70 and 95%. The viruses also produce disease of varying symptomatology, skin lesions being very prominent, raised or flat. There was no obvious association between lesion type and virulence.

Tests made on the wild rabbits from which the samples were obtained, and on Inoculated domestic rabbits, showed that virulence could not be predicted by gel-diffusion tests.

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 2 , June 1965 , pp. 175 - 185
Copyright
Copyright © Cambridge University Press 1965

References

Andrewes, C. H., Thompson, H. V. & Manst, W. (1959). Myxomatosis: present position and future prospects in Great Britain. Nature, Lond., 184, 1179.CrossRefGoogle ScholarPubMed
Armour, C. J. & Thompson, H. V. (1955). Spread of myxomatosis in the first outbreak in Great Britain. Ann. appl. Biol. 43, 511.CrossRefGoogle Scholar
Burnet, F. M. (1955). The Principles of Animal Virology pp. 436–7. New York: Academic Press.Google Scholar
Chapple, P. J. & Bowen, E. T. W. (1963). A note on two attenuated strains of myxoma virus isolated in Great Britain. J. Hyg., Gamb., 61, 161.CrossRefGoogle ScholarPubMed
Chapple, P. J., Bowen, E. T. W. & Lewis, N. D. (1963). Some observations on the use of the Ouchterlony gel diffusion technique in the study of myxomatosis. J. Hyg., Camb., 61, 373.CrossRefGoogle Scholar
Fenner, F. & Marshall, I. D. (1955). Occurrence of attenuated strains of myxoma virus in Europe. Nature, Lond., 176, 782.CrossRefGoogle ScholarPubMed
Fenner, F. & McIntyre, G. A. (1956). Infectivity titrations of myxoma virus in the rabbit and the developing chick embryo. J. Hyg., Camb., 54, 246.CrossRefGoogle ScholarPubMed
Fenner, F. & Marshall, I. D. (1957). A comparison of the virulence for European rabbits (Oryctolagus cuniculus) of strains of myxoma virus recovered in the field in Australia, Europe and America. J. Hyg., Camb., 55, 149.CrossRefGoogle ScholarPubMed
Fenner, F. (1965). Viruses of the myxoma-fibroma subgroup of the poxviruses. II. Comparison of soluble antigens by gel diffusion tests. Aust. J. exp. Biol. 43, 143.CrossRefGoogle ScholarPubMed
Fenner, F. & Ratcliffe, F. N. (1965). Myxomatosis. Cambridge University Press (in the Press).Google Scholar
Hudson, J. R. & Mansi, W. (1955). Attenuated strains of myxoma virus in England. Vet. Rec. 67, 746.Google Scholar
Jacotot, H., Vallée, A. & Virat, B. (1955). Apparition en France d'un mutant naturellement atténué du virus de Sanarelli. Ann. Inst. Pasteur, 89, 361.Google ScholarPubMed
Mansi, W. & Thomas, V. (1958). Serological investigations in the study of myxoma and fibroma viruses. II. The gel diffusion precipitation test. J. comp. Path. 68, 188.CrossRefGoogle Scholar
Marshall, I. D. (1959). The influence of ambient temperature on the course of myxomatosis in rabbits. J. Hyg., Camb., 57, 484.Google ScholarPubMed
Marshall, I. D. & Fenner, F. (1960). Studies in the epidemiology of infectious myxomatosis of rabbits. VII. The virulence of strains of myxoma virus recovered from Australian wild rabbits between 1951 and 1959. J. Hyg., Camb., 58, 485.Google ScholarPubMed
Mead-Briggs, A. R. (1964 a). Some experiments concerning the interchange of rabbit fleas, Spilopsyllus cuniculi (Dale) between living rabbit hosts. J. Anim. Ecol. 33, 13.CrossRefGoogle Scholar
Mead-Briggs, A. R. (1964 b). Records of rabbit fleas, Spilopsyllus cuniculi (Dale), from every county in Great Britain with notes on infestation rates. Ent. mon. Mag. 100, 8.Google Scholar
Mead-Briggs, A. R. & Page, R. J. C. (1964). Fleas other than Spilopsyllus cuniculi (Dale), from a collection of rabbits, predominantly myxomatous, obtained throughout Great Britain. Ent. Gaz. 15, 60.Google Scholar
Moses, A. (1911). O virus do mixoma dos coelhos. Mem. Inst. Oswaldo Cruz, 3, 46.CrossRefGoogle Scholar
Woodroofe, G. M. & Fenner, F. (1965). Viruses of the myxoma-fibroma subgroup of the poxviruses. I. Growth and plaque production in cultured cells, and cross-protection tests in rabbits. Aust. J. exp. Biol. 43, 123.CrossRefGoogle Scholar