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Experimental intestinal coliform infections in mice

Published online by Cambridge University Press:  15 May 2009

Frances M. Ashburner  and
Rose Mushin
Frances M. Ashburner
Affiliation:
The School of Bacteriology, University of Melbourne, Parkville, Victoria, Australia
Rose Mushin
Affiliation:
The School of Bacteriology, University of Melbourne, Parkville, Victoria, Australia
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A technique involving the suppression of normal intestinal flora with antibiotics, and the introduction of streptomycin-resistant coliforms was used for the study of infections in mice.

It was shown that Escherichia coli, both the enteropathogenic and normal faecal strains, tend to colonize the upper intestinal tract as well as the lower region. An oral dose of ten or less cells could produce a chronic infection. Infections were asymptomatic even with an initial dose of 109 bacteria. There was no indication of growth advantages for enteropathogenic coliforms in competition with normal.

Type
Research Article
Information
Journal of Hygiene , Volume 60 , Issue 2 , June 1962 , pp. 175 - 181
Copyright
Copyright © Cambridge University Press 1962

References

REFERENCES

Bohnhoff, M., Drake, B. L. & Miller, C. P. (1954). Effect of streptomycin on susceptibility of intestinal tract to experimental Salmonella infection. Proc. Soc. exp. Biol. Med., N.Y., 86, 132.Google Scholar
Braun, O. H., Resemann, G. & Stöckle, Ch. (1953). Untersuchungen über die Tierpathogenität der Dyspepsiecolibakterien. Z. Hyg. InfektKr. 137, 581.Google Scholar
Cooper, G. N. (1959). Experimental shigellosis in mice. I. Aust. J. exp. Biol. med. Sci. 37, 193.CrossRefGoogle ScholarPubMed
Cooper, G. N. & Pillow, J. A. (1959). Experimental shigellosis in mice. II. Aust. J. exp. Biol. med. Sci. 37, 201.Google Scholar
Cregan, J. & Hayward, N. J. (1953). The bacterial content of the healthy human small intestine. Brit. med. J. i, 1356.Google Scholar
Freter, R. (1955). The fatal enteric cholera infection in the guinea-pig achieved by inhibition of normal enteric flora. J. inf. Dis. 97, 57.Google Scholar
Freter, R. (1956). Experimental enteric Shigella and Vibrio infections in mice and guinea pigs. J. exp. Med. 104, 411.Google Scholar
Hicks, J. D. & Matthaei, E. (1958). A selective fluorescence stain for mucin. J. Path. Bact. 75, 473.CrossRefGoogle ScholarPubMed
Jawetz, E., Melnick, J. L. & Adelberg, E. A. (1960). Review of Medical Microbiology. 4th edn.Los Altos, California: Lange Medical Publications.Google Scholar
Kauffmann, F. (1954). Enterobacteriaceae. Copenhagen: Einar-Munksgaard.Google Scholar
Koya, G., Kosakai, N., Kono, M., Mori, M. & Fukasawa, Y. (1954). Observations on the multiplication of Escherichia coli 0111: B4 in the intestinal tract of adult volunteers in feeding experiments. Jap. J. med. Sci. Biol. 2, 197.Google Scholar
Leifson, E. (1953). New culture media based on sodium desoxycholate for the isolation of intestinal pathogens and for the enumeration of colon bacilli in milk. J. Path. Bact. 40, 581.Google Scholar
Mushin, R., Lowson, F. M. & Bishop, R. F. (1960). Bacteriological and epidemiological studies on coliform diarrhoea in children. Med. J. Aust. ii, 365.Google Scholar
Neter, E. (1959). Enteritis due to enteropathogenic Escherichia coli. J. Pediat. 55, 223.CrossRefGoogle ScholarPubMed
Neter, E., Bertram, L. F. & Arbesman, C. E. (1952). Demonstration of Escherichia coli 055 and 0111 antigens by means of hemagglutination test. Proc. Soc. exp. Biol. Med., N.Y. 79, 255.CrossRefGoogle ScholarPubMed
Olitzki, A. L. (1956). Investigations on infantile gastro-enteritis in Jerusalem 1953–1956. Acta med. or., Jerusalem, 15, 137.Google Scholar
Taylor, J., Wilkins, M. P. & Payne, J. M. (1961). Relation of rabbit gut reaction to enteropathogenic Escherichia coli. Brit. J. exp. Path. 42, 43.Google ScholarPubMed
Thomson, S. (1955). The role of certain varieties of Bacterium coli in gastro-enteritis of babies. J. Hyg., Camb., 53, 357.Google Scholar