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Haemolytic disease of newborn foals due to iso-immunization of pregnancy

Published online by Cambridge University Press:  15 May 2009

R. R. A. Coombs ,
R. C. Crowhurst ,
F. T. Day ,
D. H. Heard ,
I. T. Hinde ,
J. Hoogstraten  and
H. B. Parry
R. R. A. Coombs
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
R. C. Crowhurst
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
F. T. Day
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
D. H. Heard
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
I. T. Hinde
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
J. Hoogstraten
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
H. B. Parry
Affiliation:
From the Department of Pathology, University of Cambridge, and the Animal Health Trust, Newmarket
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1. Six cases of haemolytic disease in newborn foals apparently due to iso-immunization of pregnancy are described from their clinical, serological, haematological and pathological aspects. The findings agree closely with those seen in the same disease in newborn mules.

2. The disease may be diagnosed serologically by demonstrating the in vivo iso-sensitization of the foal's red cells by means of the direct antiglobulin-sensitization test. It is quite possible that after further investigation a modification of Diamond's albumin tube test may also be of value. Immune anti-red cell iso-antibodies of more than one specificity may be demonstrated in the dams' sera.

3. Despite the acute haemolytic process, very few reticulocytes and no erythroblasts are seen in the peripheral blood.

4. The morbid histology of the tissues of foals dying with the disease exhibits various points of interest which are discussed.

5. The clinical aspect is not described in this paper in any detail. However, a programme is suggested which would enable a successful exsanguino-transfusion of compatible blood to be carried out at very short notice. At present this seems to be the logical and most practical method of specific treatment.

Type
Research Article
Information
Journal of Hygiene , Volume 46 , Issue 4 , December 1948 , pp. 403 - 418
Copyright
Copyright © Cambridge University Press 1948

References

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