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The immune response to infection with vaccinia virus in mice: II. Appearance of hypersensitivity, production of macrophage migration inhibitory factor and transformation of spleen cells in response to virus antigens

Published online by Cambridge University Press:  15 May 2009

Lindsey M. Hutt
Lindsey M. Hutt
Affiliation:
Department of Virology, The Lister Institute of Preventive Medicine, Chelsea Bridge Road, London SW 1 W 8RH
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The appearance of specific hypersensitivity to virus antigens was examined in mice infected intravenously with vaccinia virus. Both immediate hypersensitivity, transferable by serum, and delayed-type hypersensitivity, transferable only by cells, were apparent 8 days after infection and demonstrable for at least a further 130 days. Production of macrophage migration inhibitory factor by lymphocytes from infected mice was measured directly in terms of inhibition of migration by antigen or indirectly by determining the effect of soluble factors elaborated by the stimulated lymphocytes. The irregular results may have been the resultants of antigen-mediated macrophage stimulation, toxicity and induction of migration inhibitory factor. Transformation of spleen cells – presumably lymphocytes – from infected mice could be induced in vitro by virus antigens for at least 139 days after infection. Virus/lymphocyte interaction appears to be a particularly fruitful area for further study.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 3 , June 1975 , pp. 315 - 327
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Al-Asuari, S., David, J. R., Lawrence, H. S. & Thomas, L. (1965). In vitro studies on homograft sensitivity. Nature, London 205, 916.CrossRefGoogle Scholar
Allen, E. G. & Mudd, S. (1973). Protection of mice against vaccinia virus by bacterial infection and sustained stimulation with specific bacterial antigens. Infection and Immunity 7, 62.Google Scholar
Blanden, R. V. (1971). Mechanisms of recovery from a generalized infection: mousepox III. Regression of infectious foci. Journal of Experimental Medicine 133, 1090.CrossRefGoogle Scholar
Bloom, B. R. (1971). In vitro approaches to the mechanism of cell-mediated immune reactions. Advances in Immunology 13, 101.CrossRefGoogle Scholar
Boulter, E. A. (1969). Protection against poxviruses. Proceedings of the Royal Society of Medicine 62, 295.CrossRefGoogle ScholarPubMed
Collins, F. M. & Mackaness, G. B. (1968). Delayed hypersensitivity and Arthus reactivity in relation to host resistance in Salmonella-infected mice. Journal of Immunology 101, 830.CrossRefGoogle ScholarPubMed
Dvorak, H. F. & Hirsch, M. S. (1971). Role of basophilic leukocytes in cellular immunity to vaccinia virus infection. Journal of Immunology 107, 1576.Google Scholar
Feinstone, S. M., Beachey, E. H. & Rytel, M. W. (1969). Induction of delayed hypersensitivity to influenza and mumps virus in mice. Journal of Immunology 103, 844.CrossRefGoogle ScholarPubMed
George, M. & Vaughan, J. H. (1962). In vitro cell migration as a model for delayed hypersensitivity. Proceedings of the Society for Experimental Biology and Medicine 111, 514.CrossRefGoogle Scholar
Glasgow, L. A. (1970). Cellular immunity in host resistance to viral infections. Archives of Internal Medicine 126, 125.CrossRefGoogle ScholarPubMed
Halstead, S. B., Chow, J. S. & Marchette, N. J. (1973). Immunological enhancement of dengue virus replication. Nature New Biology 243, 24.Google ScholarPubMed
Hutt, L. M. (1975). The immune response to infection with vaccinia virus in mice I. Infection and production of antibody neutralizing cell-associated and cell-free virus. Journal of Hygiene 74, 301.Google Scholar
Matsanstiotis, N. S. & Tsenghi, C. J. (1964). Mitosis in leucocyte cultures. Lancet i, 989.CrossRefGoogle Scholar
Miller, G. & Enders, J. F. (1968). Vaccinia virus replication and cytopathic effect in cultures of phytohaemagglutinin-treated human peripheral blood leukocytes. Journal of Virology 2, 787.CrossRefGoogle Scholar
Neiburger, R. G. & Youmans, G. P. (1973). Inhibition of mouse macrophages by tuberculin-sensitive mouse lymphocytes and by mouse migration inhibitory factor. Infection and Immunity 7, 190.CrossRefGoogle ScholarPubMed
North, R. J. (1969). Cellular kinetics associated with the development of acquired cellular resistance. Journal of Experimental Medicine 130, 299.CrossRefGoogle ScholarPubMed
Oppenheim, J. J. (1968). Relationship of in vitro transformation to delayed hypersensitivity in guinea pigs and man. Federation Proceedings. Federation of American Societies for Experimental Biology 27, 21.Google Scholar
Phillips, S. M., Carpenter, C. B. & Merrillsten, J. P. (1972). Cellular immunity in the mouse. II. Correlations of in vivo and in vitro phenomena. Cellular Immunology 5, 249.CrossRefGoogle ScholarPubMed
Robinson, L. C. & Kaplan, C. (1969). A method for the purification, concentration and inactivation of vaccinia virus. Progress in Immunobiological Standardization 3, 170.Google Scholar
Rosenberg, G. L., Farber, P. A. & Notrins, A. L. (1972). In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vaccinia virus. Proceedings of the National Academy of Sciences, U.S.A. 69, 756.CrossRefGoogle ScholarPubMed
Sandok, P. L., Hinsdill, R. D. & Albrecht, R. M. (1971). Migration inhibition of mouse macrophages by Brucella antigens. Infection and Immunity 4, 516.CrossRefGoogle ScholarPubMed
Smith, K. A., Chess, L. & Mardiney, M. R. (1972). The characteristics of lymphocyte tritiated thymidine incorporation in response to mumps virus. Cellular Immunology 5, 597.CrossRefGoogle ScholarPubMed
Tubergen, D. G. & Oldstone, M. B. E. (1971). Release of macrophage migration inhibitory factor by virus-infected spleen cells. Journal of Immunology 107, 1483.CrossRefGoogle ScholarPubMed
Ueda, S. & Nozima, T. (1969). Delayed hypersensitivity in vaccinia-infected mice, I. Antigen(s) responsible for developing delayed hypersensitivity. Acta Virologica (Praha) 13, 532.Google Scholar
Worthington, M., Rabson, A. S. & Baron, S. (1972). Mechanism of recovery from systemic vaccinia virus infection. I. The effects of cyclophosphamide. Journal of Experimental Medicine 136, 277.CrossRefGoogle ScholarPubMed