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Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting

Published online by Cambridge University Press:  19 October 2009

Walter E. P. Beyer ,
Jos T. M. Van Der Logt ,
Ruud van Beek  and
Nic Masurel
Walter E. P. Beyer
Affiliation:
Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
Jos T. M. Van Der Logt
Affiliation:
Department of Medical Microbiology, University of Nijmegen, The Netherlands
Ruud van Beek
Affiliation:
Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
Nic Masurel
Affiliation:
Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
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Fifty volunteers, treated with an inactivated trivalent influenza vaccine containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 virus, were subdivided according to the estimated first exposure to influenza in their lifetime (priming) and the presence of antibodies against the vaccine components in the pre-vaccination sera. The isotypic antibody response (IgG, IgA, IgM) was determined by means of an antibody capture haemadsorption immunosorbent technique. For all three vaccine components, previously seropositive subjects produced antibodies of the IgG- and IgA-class more frequently than previously seronegative persons. Subjects primed to one of the influenza A subtypes showed more IgG and IgA responses in comparison with those unprimed (prime-effect). In contrast, IgM antibodies occurred in only 19 and 11% of primed, but in 59 and 54% of unprimed subjects, for A (H3N2) and A (HlNl), respectively. The incidence of IgM titre rises was not influenced by the prevaccination state. However, the mean magnitude of anti-A(H1N1)-IgM titre rises was greater in those previously seronegative. The concepts of primary and reinfection and of ‘original antigenic sin’ are discussed, and it is suggested that age and, if possible, serological state prior to antigen-exposure should be taken into account when studying isotypic antibody responses after influenza infection or vaccination.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 3 , June 1986 , pp. 513 - 522
Copyright
Copyright © Cambridge University Press 1986

References

REFERENCES

Berlin, B. S.McQueen, J. L., Minuse, E. & Davenport, F. M. (1963). A method for increasing the sensitivity of the hemagglutination-inhibition test with equine influenza virus. Virology 21, 665–666.CrossRefGoogle ScholarPubMed
Boyer, K. M., Cherry, J. D. & Noble, G. R. (1977). IgM and IgG antibody responses following immunization of children and adults with influenza A/NJ/76 vaccines. In II nd International Symposium on Influenza Immunization, Geneva 1977: Developments in Biological Standardization 39, 303–308. Basel: S. Karger.Google Scholar
Burlington, D. B., Clements, M. L., Meiklejohn, G., Phelan, M. & Murphy, B. R. (1983). Hemagglutinin-specific antibody responses in immunoglobulin G, A, and M isotypes as measured by enzyme-linked immunosorbent assay after primary or secondary infection of humans with influenza A virus. Infection and Immunity 41, 540–545.CrossRefGoogle ScholarPubMed
Döller, P. C., Döller, G. & Gerth, H.-J. (1985). Immunofluorescence test with antigen-loaded erythrocytes: Detection of influenza virus specific IgG, IgA, and IgM antibodies. Medical Microbiology and Immunology 173, 291–302.CrossRefGoogle ScholarPubMed
Dowdle, W. R., Coleman, M. T., Hall, E. C., Knez, V. (1969). Properties of the Hong Kong influenza virus. 2. Antigenic relationship of the Hong Kong virus haemagglutinin to that of other human influenza A viruses. Bulletin of the World Health Organization 41, 419–424.Google Scholar
Francis, T., Davenport, F. M. & Hennessy, A. V. (1953). A serologic recapitulation of human infection with different strains of influenza virus. Transactions of the Association of American Physicians 66, 231–239.Google ScholarPubMed
Goldwater, P. N., Webster, M. & Banatvala, J. E. (1982). Use of a simple, new test for virus-specific IgM to investigate an outbreak of influenza B in a hospitalised aged community. Journal of Virological Methods 4, 9–18.CrossRefGoogle Scholar
Gonchoroff, N. J., Kendal, A. P., Phillips, D. J. & Reimer, C. B. (1981). Immunoglobulin M and G antibody response to type-and subtype-specific antigens after primary and secondary exposures of mice to influenza A viruses. Infection and Immunity 36, 510–517.CrossRefGoogle Scholar
Goodeve, A. C., Jennings, R. & Potter, C. W. (1983). The use of the single radial haemolysis test for assessing antibody response and protective antibody levels in an influenza B vaccine study. Journal of Biological Standardization 11, 289–296.CrossRefGoogle Scholar
Julkunen, I., Hovi, T., Seppala, I. & Makela, O. (1985). Immunoglobulin G subclass antibody responses in influenza A and parainfluenza type 1 virus infections. Clinical and Experimental Immunology 60, 130–138.Google ScholarPubMed
Julkunen, I., Pyhälä, R. & Hovi, T. (1985). Enzyme immunoassay, complement fixation and hemagglutination inhibition tests in the diagnosis of influenza A and B virus infections. Purified hemagglutinin in subtype-specific diagnosis. Journal of Virological Methods 10, 75–84.CrossRefGoogle Scholar
Leibenzon, A. S. (1984). Seroconversion of antihemagglutinins in fractions of iminunoglobulins of various classes after vaccination with inactivated influenza vaccine. Laboratornoe Delo (Moskva) 7, 408–409.Google Scholar
Masurel, N. (1968). Antibody response obtained by vaccination with the influenza A/equi 2 virus in man. Nature 218, 100–101.CrossRefGoogle ScholarPubMed
Masurel, N. & André, F. E. (1978). Antibody response against current H1N1 influenza virus after vaccination with last season's trivalent vaccine. Lancet i, 144–145.CrossRefGoogle Scholar
Masurel, N. & Marine, W. M. (1973). Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man. American Journal of Epidemiology 97, 44–49.CrossRefGoogle ScholarPubMed
Masurel, N., Ophof, P. & De Jong, P. (1981). Antibody response to immunization with influenza A/USSR/77 (HlNl) virus in young individuals primed or unprimed for A/New Jersey/76 (HlNl) virus. Journal of Hygiene 87, 201–209.CrossRefGoogle Scholar
Murphy, B. R.Nelson, D. L., Wright, P. F., Tierney, E. L., Phelan, M. A. & Chanock, R. M. (1982). Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines. Infection and Immunity 36, 1102–1108.CrossRefGoogle ScholarPubMed
Schild, G. C.Pereira, M. S. & Chakraverty, P. (1975). Single-radial-haemolysis: a new method for the assay of antibody to influenza haemagglutinin. Applications for diagnosis and seroepidemiologic surveillance of influenza. Bulletin of the World Health Organization 52, 43–50.Google ScholarPubMed
Stuart-Harris, C. H. & Schild, G. C. (1976). Immunity in influenza. In Influenza, the Viruses atid the Disease, 1st ed., pp. 144–164. London: Edward Arnold.Google Scholar
Tyrrell, D. A. J. & Smith, J. W. G. (1979). Vaccination against influenza A. British Medical Bulletin 35, 77–85.CrossRefGoogle ScholarPubMed
Van Der Logt, J. T. M., Beyer, W., Van Loon, A., Heessen, F. & Van Der Veen, J. (1984). Diagnosis of influenza A and B infections by detection of isotypic antibody response. In Sixth International Congress of Virology, 09 1–7, 1984, abstract P 33–13, p. 30. Japan: Sendai.Google Scholar
Van Der Logt, J. T. M., Van Loon, A. M., Heessen, F. W. A. & Van Der Veen, J. (1985). Diagnosis of parainfluenza virus infection in children and older patients by detection of specific IgM antibody. Journal of Medical Virology 16, 191–199.CrossRefGoogle ScholarPubMed
Van Der Logt, J. T. M., Van Loon, A. M. & Van Der Veen, J. (1981). Hemadsorption immunosorbent technique for determination of rubella immunoglobulin M antibody. Journal of Clinical Microbiology 13, 410–415.CrossRefGoogle ScholarPubMed
Wiley, D. C., Wilson, I. A. & Skehel, J. J. (1981). Structural identification of the antibody binding sites of Hong Kong influenza hemagglutinin and their involvement in antigenic variation. Nature 289, 373–378.CrossRefGoogle ScholarPubMed