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Immunological enhancement and the pathogenesis of dengue haemorrhagic fever

Published online by Cambridge University Press:  25 March 2010

J. S. Porterfield
Affiliation:
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE
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Laboratory studies have provided evidence that the replication of dengue viruses in preparations of primary peripheral blood mononuclear cells of human or simian origin, or in macrophage-like cell lines of human or murine origin, may be enhanced by sub-neutralizing concentrations of homotypic dengue antibody, by heterotypic dengue antibody, or by antibody against heterologous flaviviruses. The mechanism underlying this phenomenon is discussed in the context of dengue haemorrhagic fever and the dengue shock syndrome.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1982

References

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