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The importance of P and type 1 fimbriae for the persistence of Escherichia coli in the human gut

Published online by Cambridge University Press:  15 May 2009

K. Tullus ,
I. Kühn ,
I. Ørskov ,
F. Ørskov  and
R. Möllby
K. Tullus
Affiliation:
Department of Pediatrics, Karolinska Institute, S:t Göran's Children's Hospital, S-112 81 Stockholm, Sweden
I. Kühn
Affiliation:
Department of Bacteriology, Karolinska Institute, S-104 01 Stockholm, and Swedish National Bacteriological Laboratory, S-105 21 Stockholm, Sweden
I. Ørskov
Affiliation:
Collaborative Centre for Reference and Research on Escherichia (World Health Organisation), Statens Seruminstitut, Copenhagen, Denmark
F. Ørskov
Affiliation:
Collaborative Centre for Reference and Research on Escherichia (World Health Organisation), Statens Seruminstitut, Copenhagen, Denmark
R. Möllby
Affiliation:
Department of Bacteriology, Karolinska Institute, S-104 01 Stockholm, and Swedish National Bacteriological Laboratory, S-105 21 Stockholm, Sweden
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The faecal Escherichia coli flora was studied in 89 infants. Each infant was followed with a mean of 12 faecal samples (range 5–21) between 0 and 18 months of age. All isolates were assayed for P fimbriae and biochemically phenotyped and the persistence of each strain (phenotype) in the infant's gut was determined. In a subset of strains the occurrence of type 1 fimbriae and adherence to HeLa cells was studied. Thirty-one per cent of isolates belonging to strains colonizing for longer than 6 months expressed P fimbriae compared to 19% of the isolates from strains colonizing 1–6 months or transient strains colonizing less than 1 month. Type 1 fimbriae and adherence to HeLa cells occurred similarly often in all groups of strains. We conclude that P fimbriae, but not type 1 fimbriae or HeLa cell adherence seemed to contribute to the ability of the E. coli strain to colonize the human intestine.

Type
Research Article
Information
Epidemiology & Infection , Volume 108 , Issue 3 , June 1992 , pp. 415 - 421
Copyright
Copyright © Cambridge University Press 1992

References

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