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In vitro comparison of foot-and-mouth disease virus subtype variants causing disease in vaccinated cattle

Published online by Cambridge University Press:  15 May 2009

E. C. Anderson ,
W. J. Doughty ,
J. Anderson  and
D. Baber
E. C. Anderson
Affiliation:
Wellcome Institute for Research on Foot-and-Mouth Disease, Box 18021, Embakasi, Nairobi, Kenya
W. J. Doughty
Affiliation:
Wellcome Institute for Research on Foot-and-Mouth Disease, Box 18021, Embakasi, Nairobi, Kenya
J. Anderson
Affiliation:
Wellcome Institute for Research on Foot-and-Mouth Disease, Box 18021, Embakasi, Nairobi, Kenya
D. Baber
Affiliation:
Wellcome Institute for Research on Foot-and-Mouth Disease, Box 18021, Embakasi, Nairobi, Kenya
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Summary

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Foot-and-mouth disease virus isolates of types O, A and SAT 2, from diseased animals in herds routinely vaccinated twice a year were compared antigenically with the vaccine strains in the complement-fixation, neutralization and radial immunodiffusion tests. It was found that strains which had readily infected vaccinated cattle had R values against the vaccine strain in the complement- fixation and radial immunodiffusion tests of 30 or less, while strains causing primary outbreaks with little spread had R values of 30–40. Threefold differences in humoral neutralizing antibody concentration between the field variant and the vaccine strain in sera from vaccinated animals were likely to be significant in terms of protection.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 3 , June 1978 , pp. 451 - 459
Copyright
Copyright © Cambridge University Press 1978

References

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