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Intra-uterine transmission of cytomegalovirus in women known to be immune before conception

Published online by Cambridge University Press:  19 October 2009

P. D. Griffiths  and
C. Baboonian
P. D. Griffiths
Affiliation:
Department of Virology, Medical College of St Bartholomew's Hospital, London E.C.1
C. Baboonian
Affiliation:
Department of Virology, Medical College of St Bartholomew's Hospital, London E.C.1
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Summary

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A prospective study identified 785 pregnant women who had been shown to possess complement fixing antibodies against cytomegalovirus (CMV) during a previous pregnancy. As these women were thus known to have been immune prior to their subsequent conception, their neonates were examined for evidence of congenital CMV infection. Specimens were obtained from 725(92%) of the neonatcs and congenital infection was found in only one (0·14%). The elder sister of the infected child was also shown, by retrospective testing of her stored cord serum for specific IgM antibodies, to have been infected in utero. Thus, one woman was identified who had delivered consecutive siblings congenitally infected with CMV. We conclude that some women have a propensity for intra-uterine transmission of CMV, despite being immune prior to conception, and speculate that such women may have acquired their infections perinatally.

Type
Research Article
Information
Journal of Hygiene , Volume 92 , Issue 1 , February 1984 , pp. 89 - 95
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Alford, C. A., Stagno, S. & Pass, R. F. (1980). Natural history of perinatal oytomegaloviral infection. In Perinatal Infections, pp. 125–147. Ciba Foundation – Excerpta Medica, Amsterdam.Google Scholar
Embil, J. A., Ozere, R. L. & Haldane, E. V. (1970). Congenital cytomegalovirus infection in two siblings from consecutive pregnancies. Journal of Pediatrics 77, 417–421.Google Scholar
Festenstein, H., Adams, E., Burke, J., Oliver, R. T. D., Sacks, J. A. & Wolfe, E. (1972). The distribution of HL-A antigens in ex-patriots from East Bengal living in London. In Histocompatibility Testing(ed. Dausset, J. and Colombani, J.), pp. 175–178. Copenhagen: Munksgaard.Google Scholar
Grant, S., Edmond, E. & Syme, J. (1981). A prospective study of cytomegalovirus infection in pregnancy. Journal of Infection 3, 24–31.Google Scholar
Griffiths, P. D. (1981). The presumptive diagnosis of primary cytomegalovirus infection in early pregnancy by means of a radioimmunoassay for specific IgM antibodies. British Journal of Obstetrics and Gynaecology 88, 582–587.Google Scholar
Griffiths, P. D. (1983). Congenital cytomegalovirus infection. In Recent advances in Clinical Virology, vol. 3 (ed. Waterson, A. P.), pp. 57–71. Edinburgh: Churchill Livingstone.Google Scholar
Griffiths, P. D., Buie, K. J. & Heath, R. B. (1978). A comparison of complement fixation, indirect immunofluorescence for viral late antigens and anti-complement immunofluorescence tests for the detection of cytomegalovirus specific serum antibodies. Journal of Clinical Pathology 31, 827–831.Google Scholar
Griffiths, P. D. & Baboonian, C. (1983). A prospective study of primary cytomegalovirus infection during pregnancy: final report. British Journal of Obstetrics and Gynaecology (in the Press).Google Scholar
Griffiths, P. D., Stagno, S., Pass, R. F., Smith, R. J. & Alford, C. A. (1982). Congenital cytomegalovirus infection: diagnostic and prognostic significance of the detection of specific IgM antibodies in cord serum. Pediatrics 69, 544–540.Google Scholar
Hanshaw, J. B., Scheiner, A. P., Moxley, A. W., Gaev, L., Abel, V. & Scheiner, B. (1976). CNS effects of ‘silent’ cytomegalovirus infection. New England Journal of Medicine 295, 468–470.Google Scholar
Huang, E.-S., Alford, C. A., Reynolds, D. W., Stagno, S., Pass, R. F. (1980). Molecular epidemiology of cytomegalovirus infections in women and their infants. New England Journal of Medicine 303, 958–962.Google Scholar
Kangro, H. O. (1980). Evaluation of a radioimmunoassay for IgM class antibodies against cytomegalovirus. British Journal of Experimental Pathology 61, 512–520.Google Scholar
Krech, U., Konjajev, Z. & Jung, M. (1971). Congenital cytomegalovirus infection in siblings from consecutive pregnancies. Helvetica Paediatrica Acta 26, 355–362.Google Scholar
Peckham, C. S., Chin, K. S., Coleman, J. C., Henderson, K., Hurley, R. & Preece, P. M. (1983). Cytomegalovirus infection in pregnancy: preliminary findings from a prospective study. Lancet i, 1352–1355.Google Scholar
Pereira, R. S., James, D. C. O. & Stern, H. (1978). Correlation between cytomegalovirus infection and HLA-BW15. British Medical Journal ii, 126.Google Scholar
Preece, P. M., Blount, J. M., Glover, J., Fletcher, G. M., Peckham, C. S. & Griffiths, P. D. (1983). A study of children exposed to primary maternal cytomegalovirus infection during pregnancy. Archives of Disease in Childhood (in the Press).Google Scholar
Reynolds, D. W., Stagno, S., Hosty, T. S., Tiller, M. & Alford, C. A. (1973). Maternal cytomegalovirus excretion and perinatal infection. New England Journal of Medicine 289, 1–5.Google Scholar
Saigal, S., Lunyk, O., Larke, R. P. B. & Chernesky, M. A. (1982). The outcome in children with congenital cytomegalovirus infection. American Journal of Diseases in Children 136, 896–901.Google Scholar
Stagno, S., Reynolds, D. W., Lakeman, A., Charamella, L. J., Alford, C. A. (1973). Congenital cytomegalovirus infection; consecutive occurrence due to viruses with similar antigenic compositions. Pediatrics 52, 788–94.Google Scholar
Stagno, S., Reynolds, D. W., Huang, E.-S., Thames, S. D., Smith, R. J. & Alford, C. A. (1977). Congenital cytomegalovirus infection: occurrence in an immune population. New England Journal of Medicine 296, 1254–1258.Google Scholar
Stagno, S., Shaw, J. F., Pass, R. F. & Alford, C. A. (1980). HLA types in symptomatic congenital cytomegalovirus infections. Pediatric Reseatch 14, 565.Google Scholar
Stagno, S., Pass, R. F., Dworsky, M. E., Henderson, R. E., Moore, E. G., Walton, P. D. & Alford, C. A. (1982). Congenital cytomegalovirus infection: the relative importance of primary and recurrent maternal infection. New England Journal of Medicine 306, 945–949.Google Scholar
Stern, H. (1977). Cytomegalovirus infection in the neonate and its prevention. Postgraduate Medical Journal 53, 588–591.Google Scholar
Stern, H. & Tucker, S. M. (1973). Prospective study of cytomegalovirus in pregnancy. British Medical Journal ii, 268–270.Google Scholar