Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

M. MOLLERACH; M. REGUEIRA; L. BONOFIGLIO; R. CALLEJO; J. PACE; J. L. DI FABIO; S. HOLLINGSHEAD; D. BRILES

doi:10.1017/S0950268803001626

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54·4% were family 1, 41·6% were family 2 and 4·0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Gor, Dennis O. Ding, Xuedong Briles, David E. Jacobs, Michael R. and Greenspan, Neil S. 2005. Relationship between Surface Accessibility for PpmA, PsaA, and PspA and Antibody-Mediated Immunity to Systemic Infection by Streptococcus pneumoniae . Infection and Immunity, Vol. 73, Issue. 3, p. 1304.

Sadowy, Ewa Skoczyñska, Anna Fiett, Janusz Gniadkowski, Marek and Hryniewicz, Waleria 2006. Multilocus Sequence Types, Serotypes, and Variants of the Surface Antigen PspA in Streptococcus pneumoniae Isolates from Meningitis Patients in Poland . Clinical and Vaccine Immunology, Vol. 13, Issue. 1, p. 139.

Pimenta, Fabiana Cristina Ribeiro-Dias, Fátima Brandileone, Maria Cristina C. Miyaji, Eliane N. Leite, Luciana C. C. and Sgambatti de Andrade, Ana Lúcia S. 2006. Genetic Diversity of PspA Types among Nasopharyngeal Isolates Collected during an Ongoing Surveillance Study of Children in Brazil. Journal of Clinical Microbiology, Vol. 44, Issue. 8, p. 2838.

Hollingshead, Susan K. Baril, Laurence Ferro, Santiago King, Janice Coan, Pat and Briles, David E. 2006. Pneumococcal surface protein A (PspA) family distribution among clinical isolates from adults over 50 years of age collected in seven countries. Journal of Medical Microbiology , Vol. 55, Issue. 2, p. 215.

Tai, Stanley S. 2006. Streptococcus pneumoniaeProtein Vaccine Candidates: Properties, Activities and Animal Studies. Critical Reviews in Microbiology, Vol. 32, Issue. 3, p. 139.

Villena, Julio Racedo, Silvia Agüero, Graciela and Alvarez, Susana 2006. Yoghurt accelerates the recovery of defence mechanisms againstStreptococcus pneumoniaein protein-malnourished mice. British Journal of Nutrition, Vol. 95, Issue. 3, p. 591.

Heeg, Christiane Franken, Carmen van der Linden, Mark Al-Lahham, Adnan and Reinert, Ralf René 2007. Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children. Vaccine, Vol. 25, Issue. 6, p. 1030.

Darrieux, M. Miyaji, E. N. Ferreira, D. M. Lopes, L. M. Lopes, A. P. Y. Ren, B. Briles, D. E. Hollingshead, S. K. and Leite, L. C. C. 2007. Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated Enhancement of Complement Deposition . Infection and Immunity, Vol. 75, Issue. 12, p. 5930.

Ito, Y. Osawa, M. Isozumi, R. Imai, S. Ito, I. Hirai, T. Ishida, T. Ichiyama, S. and Mishima, M. 2007. Pneumococcal surface protein A family types of Streptococcus pneumoniae from community-acquired pneumonia patients in Japan. European Journal of Clinical Microbiology & Infectious Diseases, Vol. 26, Issue. 10, p. 739.

Darrieux, Michelle Moreno, Adriana T. Ferreira, Daniela M. Pimenta, Fabiana C. de Andrade, Ana Lúcia S. S. Lopes, Alexandre P. Y. Leite, Luciana C. C. and Miyaji, Eliane N. 2008. Recognition of pneumococcal isolates by antisera raised against PspA fragments from different clades. Journal of Medical Microbiology , Vol. 57, Issue. 3, p. 273.

Medina, Marcela Villena, Julio Vintiñi, Elisa Hebert, Elvira María Raya, Raúl and Alvarez, Susana 2008. Nasal Immunization with Lactococcus lactis Expressing the Pneumococcal Protective Protein A Induces Protective Immunity in Mice . Infection and Immunity, Vol. 76, Issue. 6, p. 2696.

Villena, Julio Medina, Marcela Raya, Raúl and Alvarez, Susana 2008. Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection. Canadian Journal of Microbiology, Vol. 54, Issue. 10, p. 845.

Melin, Merit M. Hollingshead, Susan K. Briles, David E. Hanage, William P. Lahdenkari, Mika Kaijalainen, Tarja Kilpi, Terhi M. and Käyhty, Helena M. 2008. Distribution of Pneumococcal Surface Protein A Families 1 and 2 among Streptococcus pneumoniae Isolates from Children in Finland Who Had Acute Otitis Media or Were Nasopharyngeal Carriers . Clinical and Vaccine Immunology, Vol. 15, Issue. 10, p. 1555.

Ochs, Martina M. Bartlett, William Briles, David E. Hicks, Bryony Jurkuvenas, Audra Lau, Peggy Ren, Bing and Millar, Amanda 2008. Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae. Microbial Pathogenesis, Vol. 44, Issue. 3, p. 204.

Rohatgi, Soma Dutta, Debjani Tahir, Suhail and Sehgal, Devinder 2009. Molecular Dissection of Antibody Responses against Pneumococcal Surface Protein A: Evidence for Diverse DH-Less Heavy Chain Gene Usage and Avidity Maturation. The Journal of Immunology, Vol. 182, Issue. 9, p. 5570.

Villena, Julio Medina, Marcela Racedo, Silvia and Alvarez, Susana 2010. Resistance of Young Mice to Pneumococcal Infection can be Improved by Oral Vaccination with Recombinant Lactococcus lactis. Journal of Microbiology, Immunology and Infection, Vol. 43, Issue. 1, p. 1.

Bonofiglio, Laura Regueira, Mabel Pace, Julio Corso, Alejandra García, Ernesto and Mollerach, Marta 2011. Dissemination of an Erythromycin-Resistant Penicillin-NonsusceptibleStreptococcus pneumoniaePoland6B-20 Clone in Argentina. Microbial Drug Resistance, Vol. 17, Issue. 1, p. 75.

Vadesilho, Cintia F.M. Ferreira, Daniela M. Moreno, Adriana T. Chavez-Olortegui, Carlos Machado de Avila, Ricardo A. Oliveira, Maria Leonor S. Ho, Paulo L. and Miyaji, Eliane N. 2012. Characterization of the antibody response elicited by immunization with pneumococcal surface protein A (PspA) as recombinant protein or DNA vaccine and analysis of protection against an intranasal lethal challenge with Streptococcus pneumoniae. Microbial Pathogenesis, Vol. 53, Issue. 5-6, p. 243.

Qian, J. Yao, K. Xue, L. Xie, G. Zheng, Y. Wang, C. Shang, Y. Wang, H. Wan, L. Liu, L. Li, C. Ji, W. Wang, Y. Xu, P. Yu, S. Tang, Y.-W. and Yang, Y. 2012. Diversity of pneumococcal surface protein A (PspA) and relation to sequence typing in Streptococcus pneumoniae causing invasive disease in Chinese children. European Journal of Clinical Microbiology & Infectious Diseases, Vol. 31, Issue. 3, p. 217.

Mattila, Petri S. Hammarén-Malmi, Sari Saxen, Harri Kaijalainen, Tarja Käyhty, Helena and Tarkkanen, Jussi 2012. Adenoidectomy in young children and serum IgG antibodies to pneumococcal surface protein A and choline binding protein A. International Journal of Pediatric Otorhinolaryngology, Vol. 76, Issue. 11, p. 1569.

Download full list

Article contents

Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

Abstract

Save article to Kindle

Save article to Dropbox

Save article to Google Drive

Reply to: Submit a response

Your details

You have entered the maximum number of contributors

Conflicting interests