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A Long Term Experiment with Rats on a Human Dietary

Published online by Cambridge University Press:  15 May 2009

John Boyd Orr ,
William Thomson  and
R. C. Garry
John Boyd Orr
Affiliation:
From the Rowett Research Institute, Aberdeen
William Thomson
Affiliation:
From the Rowett Research Institute, Aberdeen
R. C. Garry
Affiliation:
From the Rowett Research Institute, Aberdeen
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For 2¼ years a large colony of rats was maintained on a diet based on a dietary survey of a human population. One-half of the rats was fed on the human survey diet, or this diet with a small increase in milk, the other half on the same diet supplemented with additional milk and green food. Four generations of animals were reared, all from the same stock.

The rats on the human diet with additional milk and green food were healthy in all respects so far as can be judged from our own rats on a stock diet and from the data of other workers.

On the other hand, in spite of an exactly similar environment and heredity, the animals without additional milk and green food, showed:

(1) a slightly impaired reproductive capacity;

(2) a very markedly increased death-rate due to increased susceptibility to an infection to which all rats were equally exposed;

(3) a definitely slower rate of growth;

(4) a lower haemoglobin content in the blood; and,

(5) a clinically poorer condition as judged by behaviour and state of the coat.

These findings are discussed and the possibility of applying them to human dietetic problems briefly touched upon.

Type
Research Article
Information
Journal of Hygiene , Volume 35 , Issue 4 , December 1935 , pp. 476 - 497
Copyright
Copyright © Cambridge University Press 1935

References

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