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Neutralization kinetics studies with type SAT 2 foot-and-mouth disease virus strains. 1. Factors that influence the rate and pattern of neutralization

Published online by Cambridge University Press:  15 May 2009

M. M. Rweyemamu ,
J. C. Booth  and
T. W. F. Pay
M. M. Rweyemamu
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot-and-Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
J. C. Booth
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot-and-Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
T. W. F. Pay
Affiliation:
The Wellcome Foundation Ltd, Wellcome Foot-and-Mouth Disease Vaccine Laboratory, Pirbright, Woking, Surrey, U.K.
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A study of the kinetics of inactivation of foot-and-mouth disease virus type SAT 2 strains revealed that in most cases the rate of neutralization was not rectilinear. Deviations from first-order kinetics observed represented biphasic or parabolic and stepwise reactions. The initial rate was rapid and showed no lag phase or shoulder. The effects of deviations from linearity could be minimized by dilution of antiserum to a suitable extent. Treatment of virus–antibody mixtures with anti-species globulin resulted in enhancement of the rate of neutralization of homologous and heterologous reactions without significantly altering the relation between the two. This treatment also considerably reduced the amount of the persistent fraction. In attempt to disaggregate virus it was observed that sodium dodecyl sulphate inhibited neutralization of virus by specific antiserum.

Type
Research Article
Information
Journal of Hygiene , Volume 78 , Issue 1 , February 1977 , pp. 99 - 112
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Ashe, W. K. & Scherp, H. W. (1963). Antigenic analysis of herpes simplex virus by neutralization kinetics. Journal of Immunology 91, 658–65.CrossRefGoogle ScholarPubMed
Ashe, W. K. & Notkins, A. L. (1966). Neutralization of an infectious herpes simplex virus–antibody complex by anti-globulin. Proceedings of the National Academy of Sciences of the U.S.A. 56, 447–51.CrossRefGoogle Scholar
Ashe, W. K. & Notkins, A. L. (1967). Kinetics of sensitization of herpes simplex virus and its relationship to the reduction in the neutralization rate constant. Virology 33, 613–17.CrossRefGoogle Scholar
Bradish, C. J., Farley, J. O. & Ferrier, H. E. N. (1962). Studies on the nature of the neutralization reaction and the competition for neutralizing antibody between components of the virus system of foot-and-mouth disease. Virology 18, 378–400.CrossRefGoogle ScholarPubMed
Brown, F. & Cartwright, B. (1963). Purification of radioactive foot-and-mouth disease virus. Nature, London 199, 1168–70.Google Scholar
Buening, G. M. & Gratzek, J. B. (1967). Comparison of selected characteristics of four strains of infectious bovine rhinotracheitis virus. American Journal of Veterinary Research 28, 1257–67.Google Scholar
Capstick, P. B., Sellers, R. F. & Stewart, D. L. (1959). The neutralization of the virus of foot-and-mouth disease by immune serum. Archiv für die gesamte Virusforschung 9, 606–20.CrossRefGoogle Scholar
Cho, C. T. & Feng, K. K. (1974). Non-immunological precipitation of serum by sodium dodecyl sulphate in agar diffusion. Applied Microbiology 28, 557–60.Google Scholar
Cihak, J. (1973). Neutralization of infectious ME (Maus–Elberfield) virus–antibody complexes by anti-γ-globulin antibody. Medical Microbiology and Immunology 159, 73–82.CrossRefGoogle ScholarPubMed
Cooney, M. K., Kenny, G. E., Tam, R. & Fox, J. P. (1973). Cross relationships among 37 rhinoviruses demonstrated by virus neutralization with potent monotypic rabbit antisera. Infection and Immunity 7, 335–40.CrossRefGoogle ScholarPubMed
De Castro, M. P. (1964). Behaviour of the foot-and-mouth disease virus in cell cultures; susceptibility of the IB-RS-2 cell line. Archivos do Institute biologico, São Paulo 31, 63–78.Google Scholar
Dulbecco, R., Vogt, M. & Strickland, A. G. R. (1956). A study of the basic aspects of neutralization of two animal viruses, western equine encephalitis virus and poliomyelitis virus. Virology 2, 162–205.Google Scholar
Erickson, J. O. & Neurath, H. (1943). The serological activity of denatured antibodies. Science, New York 98, 284–5.Google Scholar
Forman, A. J. (1975). A comparison of some immunological methods for the differentiation of strains of foot and mouth disease virus. Journal of Hygiene 74, 215–25.CrossRefGoogle ScholarPubMed
Gwaltney, J. M. & Calhoun, A. M. (1970). Viral aggregation resulting in the failure to correctly identify an unknown rhinovirus. Applied Microbiology 20, 390–2.CrossRefGoogle ScholarPubMed
Hahon, N. (1969). The kinetics of neutralization of Venezuelan encephalomyelitis virus by antiserum and reversibility of the reaction. Journal of General Virology 4, 77–78.CrossRefGoogle ScholarPubMed
Haimovich, J. & Sela, M. (1969). Inactivation of bacteriophage T4, of poly-d-ananyl bacteriophage and of penicilloyl bacteriophage by immunospecifically isolated IgM and IgG antibodies. Journal of Immunology 103, 45–55.CrossRefGoogle ScholarPubMed
Hashimoto, N. & Prince, A. M. (1963). Kinetics studies on the neutralization reaction between Japanese encephalitis virus and antiserum. Virology 19, 261–72.CrossRefGoogle ScholarPubMed
Heineman, H. S. (1967). Herpes simplex neutralizing antibody-quantitation of the complement-dependent fraction in different phases of adult human infection. The Journal of Immunology 99, 214–22.CrossRefGoogle ScholarPubMed
Lafferty, K. J. (1963). The interaction between virus and antibody. I. Kinetics studies. Virology 21, 61–75.CrossRefGoogle Scholar
Mandel, B. (1961). Reversibility of the reaction between poliovirus and neutralizing antibody of rabbit origin. Virology 14, 316–28.CrossRefGoogle ScholarPubMed
Martinsen, J. S. (1971). Two plaque-size variants of foot-and-mouth disease virus differing in neutralization by guinea-pig antisera. Research in Veterinary Science 12, 399–400.CrossRefGoogle ScholarPubMed
McBride, W. D. (1959). Antigenic analysis of poliovirus by kinetics studies of serum neutralization. Virology 7, 45–58.Google Scholar
Mowat, G. N. (1962). Growth of foot-and-mouth disease virus in a fibroblastic cell line derived from hamster kidneys. Nature, London 194, 253.CrossRefGoogle Scholar
Ozaki, Y., Diwan, R., McBride, W. D. & Melnick, J. L. (1963). Antigenic characterization of oral polio-vaccine progeny by neutralization kinetics. Journal of Immunology 90, 288–96.CrossRefGoogle ScholarPubMed
Palmer, E. L., Martin, M. L., Hierholzer, J. C. & Zeigler, D. W. (1971). Nonspecific precipitation of serum proteins by sodium lauryl sulphate in agar diffusion and immunoelectrophoresis. Applied Microbiology 21, 903–6.Google Scholar
Philipson, L. (1966). Interaction between poliovirus and immunoglobulins. II. Basic aspects of virus–antibody interaction. Virology 28, 35–46.Google Scholar
Potgieter, L. N. D. & Maré, C. J. (1974). Differentiation of strains of infectious bovine rhinotracheitis virus by neutralization kinetics with late 19S rabbit antibodies. Infection and Immunity 10, 520–27.CrossRefGoogle ScholarPubMed
Putnam, F. W. & Neurath, H. (1944). The precipitation of proteins by synthetic detergents. Journal of the American Chemical Society 66, 692–7.CrossRefGoogle Scholar
Roslycky, E. B. (1969). Anomaly in the neutralization kinetics of phages of Agrobacterium radiobacter. Canadian Journal of Microbiology 15, 1033–42.Google Scholar
Roslycky, E. B. (1970). Radiobacterphage neutralization anomaly in relation to cations. Canadian Journal of Microbiology 16, 527–33.CrossRefGoogle ScholarPubMed
Rweyemamu, M. M., Booth, J. C., Parry, N. & Pay, T. W. F. (1977). Neutralization kinetics studies with type SAT 2 foot-and-mouth disease virus strains. II. Antigenic differentiation of vaccine strains. Journal of Hygiene (In the press).Google Scholar
Takabayashi, K. & McIntosh, K. (1973). Effect of heat labile factors on the neutralization of vaccine virus by human sera. Infection and Immunity 8, 582–9.CrossRefGoogle Scholar
Wagner, G. G. & Cowan, K. M. (1971). Immunochemical studies of foot-and-mouth disease. IX. Differences in neutralizing activities of guinea pig and bovine 19S and 7S antibodies. Journal of Immunology 106, 656–66.Google Scholar
Wallis, C. & Melnick, J. L. (1967). Virus aggregation as the cause of the non-neutralizable persistent fraction. Journal of Virology 1, 478–88.CrossRefGoogle ScholarPubMed
Wheeler, C. E., Briggaman, R. A. & Henderson, R. R. (1969). Discrimination between two strains (types) of herpes simplex virus by various modifications of the neutralization test. Journal of Immunology 102, 1179–92.Google Scholar