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The neutralization of pox viruses II. Relationships betweenvaccinia, rabbitpox, cowpox and ectromelia

Published online by Cambridge University Press:  15 May 2009

T. A. McNeill
T. A. McNeill
Affiliation:
Department of Microbiology, The Queen's University of Belfast
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Plaque neutralization on HEp 2 cells was used to determine the relationship between vaccinia, rabbitpox, cowpox and ectromelia using both 7 S and 19 S antibody. It was shown that for the strains of virus used vaccinia and rabbitpox were very similar but cowpox and particularly ectromelia were clearly distinguishable. The cross-titration relationships were the same for 7 S and 19 S antibody.

The titration slopes and kinetics of cross-neutralizations were interpreted on the basis of a hypothesis of antibody competition put forward in the preceding paper. It was tentatively concluded that these four viruses share a common critical antigen for neutralization and that differences in the structure or presentation of neighbouring antigens could give rise to some of the observed effects.

Type
Research Article
Information
Journal of Hygiene , Volume 66 , Issue 4 , December 1968 , pp. 549 - 555
Copyright
Copyright © Cambridge University Press 1968

References

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