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The pathogenic and immunogenic activities of Salmonella typhi in relation to its antigenic constituents

Published online by Cambridge University Press:  15 May 2009

A. Felix  and
R. Margaret Pitt
A. Felix
Affiliation:
From the Central Enteric Reference Laboratory and Bureau, Public Health Laboratory Service (Medical Research Council), London
R. Margaret Pitt
Affiliation:
From the Central Enteric Reference Laboratory and Bureau, Public Health Laboratory Service (Medical Research Council), London
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1. The most virulent strains of Salmonella typhi are those that develop both the Vi and O antigens in maximum quantities.

2. The Vi antigen is not a particularly toxic substance; it is less toxic for the mouse than the O antigen.

3. The main biological function of the Vi antigen is to protect the O antigen against the action of the natural or immune O antibody, thereby protecting the bacterial cell against phagocytosis and the bactericidal action of the serum.

4. The relative virulence for mice of freshly isolated strains of Salmonella typhi reflects their virulence for man.

Type
Research Article
Information
Journal of Hygiene , Volume 49 , Issue 1 , March 1951 , pp. 92 - 110
Copyright
Copyright © Cambridge University Press 1951

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