Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-06-02T01:45:08.126Z Has data issue: false hasContentIssue false

Poliovirus as an antigen

Published online by Cambridge University Press:  15 May 2009

K. M. Stevens
Affiliation:
Department of Virology, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Calculations have been carried out which indicate that poliovirus vaccine contains sufficient antigen to account for the observed antibody response.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1957

References

REFERENCES

Charney, J. (1956). Personal communication.Google Scholar
Dulbecco, R., Vogt, M. & Strickland, A. G. R. (1956). A study of the basic aspects of neutralization of two animal viruses, western equine encephalitis virus and poliomyelitis virus. Virology, 2, 162205.CrossRefGoogle ScholarPubMed
Edsall, G., Banton, H. J. & Wheeler, R. E. (1951). The antigenicity of single graded doses of purified diphtheria toxoid in man. Amer. J. Hyg. 53, 283–95.Google ScholarPubMed
Heidelberger, M., MacLeod, C. M., Daiser, S. J. & Robinson, B. (1946). Antibody formation in volunteers following injection of pneumococci or their type-specific polysaccharides. J. exp. Med. 83, 303–20.CrossRefGoogle ScholarPubMed
Jensen, C. (1933). Antitoxin curves in children after active immunization with diphtheria anatoxin, with special reference to the duration of antitoxic immunity. Acta path. microbiol. Scand, 10, 137–58.CrossRefGoogle Scholar
Kabat, E. A. & Mayer, M. M. (1948). Experimental Immunochemistry, Charles C. Thomas Co., Springfield, III.Google Scholar
Nelson, W. E. (1950). Mitchell-Nelson Textbook of Pediatrics, 5th ed., p. 62, W. B. Saunders Co., Philadelphia, Pa.Google Scholar
Pillemer, L., Toll, D. & Badger, S. J. (1947). Immunochemistry of toxins and toxoids. III. Isolation and characterization of diphtherial toxoid. J. biol. Chem. 170, 571–85.CrossRefGoogle Scholar
Pillemer, L. & Robbins, K. C. (1949). The chemistry of toxins. Annu. Rev. Microbiol. 3, 265–88.CrossRefGoogle Scholar
Salk, J. E. (1955). Considerations in the preparation and use of poliomyelitis virus vaccine. J. Amer. med. Assoc. 158, 1239–48.CrossRefGoogle ScholarPubMed
Salk, J. E., Bazeley, P. L. & Rotundo, R. (1955). Personal communication.Google Scholar
Schwerdt, C. E. & Schaffer, F. L. (1955). Some physical and chemical properties of purified poliomyelitis virus preparations. Ann. N.Y. Acad. Sci. 61, 740–53.CrossRefGoogle ScholarPubMed
Schwerdt, C. E. & Schaffer, F. L. (1956). Purification of poliomyelitis viruses propagated in tissue culture. Virology, 2, 665–76.CrossRefGoogle Scholar
Stevens, K. M. (1956). Some considerations of the antigen dose-antibody response relationship. J. Immunol. 76, 187–91.CrossRefGoogle ScholarPubMed