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Predicting the course of meningococcal disease outbreaks in closed subpopulations

Published online by Cambridge University Press:  01 December 1999

J. RANTA
Affiliation:
Rolf Nevanlinna Institute, P.O. Box 4, FIN-00014, University of Helsinki, Finland
P. H. MÄKELÄ
Affiliation:
National Public Health Institute, Department of Vaccines, Mannerheimintie 170 A, FIN-00300 Helsinki, Finland
A. TAKALA
Affiliation:
National Public Health Institute, Department of Vaccines, Mannerheimintie 170 A, FIN-00300 Helsinki, Finland
E. ARJAS
Affiliation:
Rolf Nevanlinna Institute, P.O. Box 4, FIN-00014, University of Helsinki, Finland
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Abstract

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A stochastic epidemic model was applied to meningococcal disease outbreaks in defined small populations such as military garrisons and schools. Meningococci are spread primarily by asymptomatic carriers and only a small proportion of those infected develop invasive disease. Bayesian predictions of numbers of invasive cases were developed, based on observed data using a stochastic epidemic model. We used additional data sets to model both disease probability and duration of carriage. Markov chain Monte Carlo sampling techniques were used to compute the full posterior distribution which summarized all information drawn together from multiple sources.

Type
Research Article
Copyright
© 1999 Cambridge University Press