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A preliminary study of the effect of contact with environmental mycobacteria on the pattern of sensitivity to a range of new Tuberculins amongst Ugandan adults

Published online by Cambridge University Press:  15 May 2009

J. L. Stanford ,
R. C. Paul ,
Andrea Penketh ,
Susan Thurlow ,
J. W. Carswell ,
D. J. P. Barker  and
Saroj Barot
J. L. Stanford
Affiliation:
School of Pathology, Middlesex Hospital Medical School, Riding House Street, London, W1P 7LD
R. C. Paul
Affiliation:
School of Pathology, Middlesex Hospital Medical School, Riding House Street, London, W1P 7LD
Andrea Penketh
Affiliation:
St Mary's Hospital Medical School, London
Susan Thurlow
Affiliation:
St Mary's Hospital Medical School, London
J. W. Carswell
Affiliation:
Department of Surgery, Mulago Hospital, Kampala, Uganda
D. J. P. Barker
Affiliation:
Faculty of Medicine, The University of Southampton
Saroj Barot
Affiliation:
East African Tuberculosis Investigations, Bacteriological Unit, Kampala, Uganda
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Summary

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A range of new Tubercul ns prepared from extracts of living organisms belonging to 12 mycobacterial species has been used to assess the effect of BCG immunization and contact with environmental mycobacteria on Ugandan adults. A total of 2,456 tests were carried out on 562 people, 86% of whom came from three areas selected for special study. These areas were chosen on the basis of occurrence of leprosy and M. ulcerans infection and on data concerning the distribution of environmental mycobacteria. It was found that the effect of BCG was small compared with that previously observed amongst Kenyan schoolchildren, but that the effect of geographical origin was considerable. There was some correlation between the percentages of reactivity to the reagents and the frequency of mycobacteria in the environment.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 2 , April 1976 , pp. 205 - 214
Copyright
Copyright © Cambridge University Press 1976

References

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