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Prevalence of Neisseria meningitidis in family members of patients with meningococcal infection

Published online by Cambridge University Press:  25 March 2010

J. A. Saez-Nieto ,
J. Campos ,
C. Latorre ,
T. Juncosa ,
M. Sierra ,
T. Garcia-Tornell ,
B. Garcia-Barreno ,
C. Lopez-Galindez  and
J. Casal
J. A. Saez-Nieto
Affiliation:
Servicio de Bacteriología, Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Majadahonda, Madrid, Spain
J. Campos
Affiliation:
Servicio de Microbiología y Unidad de Cuidados Intensivos, Hospital de San Juan de Dios, Barcelona, Spain
C. Latorre
Affiliation:
Servicio de Microbiología y Unidad de Cuidados Intensivos, Hospital de San Juan de Dios, Barcelona, Spain
T. Juncosa
Affiliation:
Servicio de Microbiología y Unidad de Cuidados Intensivos, Hospital de San Juan de Dios, Barcelona, Spain
M. Sierra
Affiliation:
Servicio de Microbiología y Unidad de Cuidados Intensivos, Hospital de San Juan de Dios, Barcelona, Spain
T. Garcia-Tornell
Affiliation:
Servicio de Microbiología y Unidad de Cuidados Intensivos, Hospital de San Juan de Dios, Barcelona, Spain
B. Garcia-Barreno
Affiliation:
Servicio de Bacteriología, Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Majadahonda, Madrid, Spain
C. Lopez-Galindez
Affiliation:
Servicio de Bacteriología, Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Majadahonda, Madrid, Spain
J. Casal
Affiliation:
Servicio de Bacteriología, Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Majadahonda, Madrid, Spain
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The aim of the study was first, to determine the prevalence of Neisseria meningitidis among the family members living with patients suffering from meningococcal infections, and second, to ascertain the distribution among these family members of strains epidemiologically related to those isolated from patients.

Forty-two family groups were studied and 135 nasopharyngeal samples were taken from family members living with patients.

Twenty family groups were found to contain meningococcal carriers, and of these 20, 13 contained a carrier of the strain that caused the infection (65%). Among the family members who were carriers, the mother and father most frequently yielded the strain which caused the illness.

The serotypes most frequently encountered both in patients and carriers were 2 and 8, as well as nontypable strains.

The polyacrylamide gel electrophoretic patterns (PAGE) most frequently found were II and IV. A notable feature of the study is the high resistance of the strains to sulphadiazine, since more than 90% of the strains found in patients and more than 75% of those from carriers possessed a minimum inhibitory concentration greater than or equal to 10μg/ml.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 1 , August 1982 , pp. 139 - 148
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Craven, D. E., Frasch, C. E., LaMocca, L. F., Rose, F. B., & Gonzalez, R. (1979). Rapid serogroup identification of Neisseria meningitidis by using antiserum agar: Prevalence of serotypes in a disease-free military population. Journal of Clinical Microbiology 10, 302–307.CrossRefGoogle Scholar
Farries, J. S., Dickson, W., Greenwood, E., Malhotra, T. R., Abbott, J. D. & Jones, D. M. (1975). Meningococcal infections in Bolton, 1971–1974. Lancet 2, 118–120.CrossRefGoogle Scholar
Frasch, C. E. (1979). Noncapsular surfage antigens of N. meningitidis. In Seminars in Infectious Diseases, vol. 2. (ed. Weinstein, L. and Field, B. N.), New York: Stratton.Google Scholar
Frasch, C. E. & Chapman, S. S. (1972 a). Classification of Neisseria meningitidis group B into distinct serotypes. I. Serological typing by a microbactericidal method. Infection and Immunity 5, 98–102.CrossRefGoogle ScholarPubMed
Frasch, C. E. & Chapman, S. S. (1972 b). Classification of Neisseria meningitidis group B into distinct serotypes. II. Extraction of type specific antigens for serotyping by precipitin techniques. Infection and Immunity 6, 127–133.CrossRefGoogle ScholarPubMed
Frasch, C. E. & Chapman, S. S. (1973). Classification of Neisseria meningitidis group B into distinct serotypes. III. Application of a new bactericidal inhibition technique to the distribution of serotypes among cases and carriers. Journal of Infectious Diseases 127, 149–154.CrossRefGoogle Scholar
Frasch, C. E. & Friedman, G. L. (1977). Identification dun serotype meningococcique associe a la maladie et common aux meningocoques des groups B, C, Y et W135. Medicine Tropical Marseille 37. 155–159.Google Scholar
Frasch, C. E. & LaMocca, L. F. (1978). Heat-modifiable outer membrane protein of N. meningitidis and their organization within the membrane. Journal of Bacteriology 136, 1127–1134.CrossRefGoogle Scholar
Frasch, C. E. & LaMocca, L. F. (1981). Determinacion del serogrupo y del serotipo en los grupos epidemiológicos de la enfermedad meningocócica. Laboratorio (Granada) 71, 437–454.Google Scholar
Frasch, C. E., McNelis, R. M. & Gotschlich, E. C. (1976). Strain-specific variation in the protein and lipopolysaccharide composition of the group B meningococcal outer membrane. Journal of Bacteriology 127, 973–981.CrossRefGoogle ScholarPubMed
Gold, R. & Wyle, F. A. (1970). New classification of Neisseria meningitidis by means of bactericidal reaction. Infection and Immunity 1, 479–484.CrossRefGoogle Scholar
Holten, E. (1979). Serotypes of N. meningitidis isolated from patients in Norway during the first six months of 1978. Journal of Clinical Microbiology 9, 186–188.CrossRefGoogle Scholar
Jones, D. M. & Tobin, B. M. (1976). Serotypes of group B meningococci. Journal of Clinical Pathology 29, 746–748.CrossRefGoogle ScholarPubMed
Marks, M. I., Frasch, C. E. & Shapera, R. M. (1979). Meningococcal colonization and infection in children and their household contacts. American Journal of Epidemiology 109, 563–571.CrossRefGoogle ScholarPubMed
Morello, J. A. & Bonhnoff, M. (1980). Neisseria and Branhamella. In Manual of Clinical Microbiology 3rd. edition (ed. Lennette, E. H., Balows, A., Hausler, W. J. and Truant, J. P.), pp. 111–129. Washington: American Society for Microbiology.Google Scholar
Saez-Nieto, J. A., Fenoll, A. & Casal, J. (1979). Serotypes of group B and C meningococci in Spain, 1978. In W.H.O. Third International Conference on Immunity and Immunization in Cerebrospinal Meningitis (Abstract), 16–17 October. Germany: Marburg/Lahn.Google Scholar
Saez-Nieto, J. A., Llacer, A., Catala, F., Fenoll, A. & Casal, J. (1981). La infeccion meningococica en Espana durante 1980. Laboratorio 71, 469–481.Google Scholar
Weber, K. & Osborn, M. (1969). The reliability of molecular weight determinations by Dodecyl Sulfate-Polvacrylamide gel electrophoresis. Journal of Biological Chemistry 244, 4406–4412.CrossRefGoogle ScholarPubMed
Zollinger, W. D. & Mandrell, R. E. (1977). Outer membrane protein and lipopolysaccharide serotyping of N. meningitidis by inhibition of a solid-phase radioimmunoassay. Infection and Immunity 18, 424–433.CrossRefGoogle Scholar
Zollinger, W. D. & Mandrell, R. E. (1980). Type-specific of group A Neisseria meningitidis: Lipopolysaccharide and heat modifiable outer membrane protein. Infection and Immunity 28, 451–458.CrossRefGoogle Scholar