Hostname: page-component-848d4c4894-4hhp2 Total loading time: 0 Render date: 2024-06-09T18:35:44.162Z Has data issue: false hasContentIssue false
  • English
  • Français

The production of neutralizing activity in serum and nasal secretion following immunization with influenza B virus

Published online by Cambridge University Press:  15 May 2009

Jean C. Downie  and
C. H. Stuart-Harris
Jean C. Downie
Affiliation:
The Virus Research Laboratory of the University of Sheffield, Lodge Moor Hospital, Sheffield
C. H. Stuart-Harris
Affiliation:
The Virus Research Laboratory of the University of Sheffield, Lodge Moor Hospital, Sheffield
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Trials were made in volunteers in 1967 and 1968 of various virus vaccines against influenza virus B. Sera and serially collected nasal washings before and after immunization were tested respectively for haemagglutination-inhibiting and tissue culture virus-neutralizing antibodies to the same strain of influenza B/Eng/65 virus as that used in the vaccines. Infection, as determined by recovery of virus and serological changes following intranasal instillation of attenuated live virus, was accompanied by the subsequent appearance of neutralizing antibodies in nasal secretion. Inactivated vaccine subcutaneously did not evoke nasal antibody formation in 1967 but did so in 1968.

In 1968 intranasal challenge of the volunteers with the attenuated virus 1 month after immunization demonstrated a correlation of susceptibility or resistance to infection with nasal and serum antibodies. Resistance appeared to depend either on a high level of serum antibodies or nasal antibodies, or both.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 2 , June 1970 , pp. 233 - 244
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Alford, R. H., Rossen, R. D., Butler, W. T. & Kasel, J. A. (1967). Neutralising and haemagglutination-inhibiting activity of nasal secretions following experimental human infection with A2 influenza virus. Journal of Immunology 98, 724.Google Scholar
Andrews, B. E., Beare, A. S., McDonald, J. C., Zuckerman, A. J. & Tyrrell, D. A. J. (1966). Further trials of live influenza vaccine. British Medical Journal i, 637.Google Scholar
Beare, A. S., Bynoe, M. L. & Tyrrell, D. A. J. (1968). Investigation into the attenuation of influenza viruses by serial passage. British Medical Journal ii, 482.CrossRefGoogle Scholar
Beare, A. S., Tyrrell, D. A. J., Hobson, D., Howells, C. H. L., Pereira, M. S., Pollock, T. M. & Tyler, L. E. (1969). Live Influenza B vaccine in volunteers. Journal of Hygiene 67, 1.CrossRefGoogle ScholarPubMed
Beare, A. S., Tyrrell, D. A. J., McDonald, J. C., Pollock, T. M., Taylor, C. E. D., Howells, C. H. L. & Tyler, L. E. (1967). Reactions and antibody response to live influenza vaccine prepared from the Iksha (A2) strain. Journal of Hygiene 65, 245.Google Scholar
Bradstreet, C. M. P. & Taylor, C. E. D. (1962). Technique of complement-fixation test applicable to the diagnosis of virus diseases. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 21, 96.Google Scholar
Cate, T. R., Rossen, R. D., Douglas, R. G. Jr, Butler, W. T. & Couch, R. B. (1966). The role of nasal secretion and serum antibody in the rhinovirus common cold. American Journal of Epidemiology 84, 352.CrossRefGoogle ScholarPubMed
Davenport, F. M. (1961). Inactivated influenza virus vaccines. American Review of Respiratory Diseases 83, 146.Google Scholar
Fleet, W. F., Couch, R. B., Cate, T. R. & Knight, V. (1965). Homologous and heterologous resistance to rhinovirus common cold. American Journal of Epidemiology 82, 185.Google Scholar
Francis, T. Jr (1940). The inactivation of epidemic influenza virus by nasal secretions of human individuals. Science, New York 91, 198.Google Scholar
Francis, T. Jr & Brightman, I. J. (1941). Virus-inactivating capacity of nasal secretions in the acute and convalescent stages of influenza. Proceedings of the Society for Experimental Biology and Medicine 48, 116.CrossRefGoogle Scholar
Francis, T. Jr, Pearson, H. E., Sullivan, E. R. & Brown, P. M. (1943). The effect of subcutaneous vaccination with influenza virus upon the virus-inactivating capacity of nasal secretions. American Journal of Hygiene 37, 294.Google Scholar
Francis, T. Jr, Sale, J. E., Pearson, H. E. & Brown, P. N. (1945). The protective effect of vaccination against induced influenza A. Journal of Clinical Investigation 24, 536.CrossRefGoogle ScholarPubMed
Gresser, I. & Dull, H. B. (1964). A virus inhibitor in pharyngeal washings from patients with influenza. Proceedings of the Society for Experimental Biology and Medicine 115, 192.CrossRefGoogle ScholarPubMed
Henle, W., Henle, G. & Stokes, J. Jr (1943). Demonstration of the efficacy of vaccination against influenza type A by experimental infection of human beings. Journal of Immunology 46, 163.Google Scholar
Hoyle, L. & Fairbrother, R. W. (1937). Isolation of the influenza virus and the relation of antibodies to infection and immunity. British Medical Journal i, 655.Google Scholar
Jao, R. L., Wheelock, E. F. & Jackson, G. G. (1965). Interferon study in volunteers infected with Asian influenza. Journal of Clinical Investigation 44, 1062.Google Scholar
Kasel, J. A., Hume, E. B., Fulk, R. V., Togo, T., Huber, M. & Hornick, R. B. (1969). Antibody responses in nasal secretions and serum of elderly persons following local or parenteral administration of inactivated influenza virus vaccine. Journal of Immunology 102, 555.Google Scholar
Lidwell, O. M. & Williams, R. E. O. (1961). The epidemiology of the common cold. II. Cross-infection and immunity. Journal of Hygiene 59, 321.CrossRefGoogle ScholarPubMed
Mann, J. J., Waldman, R. H., Togo, Y., Heiner, G. G., Dawkins, A. T. & Kasel, J. A. (1968). Antibody response in respiratory secretions of volunteers given live and dead influenza virus. Journal of Immunology 100, 726.Google Scholar
McDonald, J. C., Zuckerman, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. British Medical Journal i, 1036.Google Scholar
Mulder, J., Brans, L. M. & Hers, J. F. Ph. (1952). Studies on the increase of antibodies in nasal secretions of human beings after intracutaneous vaccination with influenza virus with the aid of the haemagglutination-inhibition technique. Antonie van Leeuwenhoek 18, 131.Google Scholar
Report of Committee on Clinical Trials or Influenza Vaccine (M.R.C.) (1958). Trials of Asian influenza vaccine. British Medical Journal i, 415.Google Scholar
Rickard, E. R., Horsfall, F. L., Hirst, G. K. & Lennette, E. H. (1941). The correlation between neutralizing antibodies in serum against influenza viruses and susceptibility to influenza in man. Public Health Reports, Washington 56, 1819.CrossRefGoogle Scholar
Salk, J. E., Pearson, H. E., Brown, P. N. & Francis, T. Jr (1945). Protective effect of vaccination against induced influenza B. Journal of Clinical Investigation, 24, 547.Google Scholar
Schulman, J. L., Khakpour, M. & Kilbourne, E. D. (1968). Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice. Journal of Virology 2, 778.Google Scholar
Sigel, M. M., Kitts, A. W., Light, A. B. & Henle, W. (1950). The recurrence of influenza A-prime in a boarding school after 2 years. Journal of Immunology 64, 33.Google Scholar
Smith, C. B., Purcell, R. H., Bellanti, J. A. & Chanock, R. M. (1966). Protective effect of antibody to parainfluenza type 1 virus. New England Journal of Medicine 275, 1145.CrossRefGoogle ScholarPubMed
Stuart-Harris, C. H., Andrewes, C. H. & Smith, W. (1938). Study of epidemic influenza with special reference to the 1936–37 epidemic. Medical Research Council. Special Report Series No. 228.Google Scholar
Tremonti, L. P., Lin, J-S.L. & Jackson, G. G. (1968). Neutralising activity in nasal secretions and serum in resistance of volunteers to parainfluenza virus type 2. Journal of Immunology 101, 572.Google Scholar
Waldman, R. H., Kasel, J. A., Fulk, R. V., Togo, Y., Hornick, R. B., Heiner, G. G., Dawkins, A. T. Jr & Mann, J. J. (1968). Influenza antibody in human respiratory secretions after subcutaneous or respiratory immunization with inactivated virus. Nature, London 218, 594.Google Scholar