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Seroprevalence of SARS coronavirus antibody in household contacts

Published online by Cambridge University Press:  08 July 2005

C.-C. LEE ,
S.-Y. CHEN ,
I.-J. CHANG ,
P.-C. TSAI ,
T.-C. LU ,
P.-L. WU ,
W.-J. CHEN ,
L.-M. HUANG  and
S.-C. CHANG
C.-C. LEE
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
S.-Y. CHEN
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
I.-J. CHANG
Affiliation:
Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan
P.-C. TSAI
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
T.-C. LU
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
P.-L. WU
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
W.-J. CHEN
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
L.-M. HUANG
Affiliation:
Division of Infectious Disease, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
S.-C. CHANG
Affiliation:
Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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Abstract

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Between March and July 2003, 671 cases of severe acute respiratory syndrome (SARS) were diagnosed in Taiwan with a total of 84 fatalities. After the epidemic, a serological survey was conducted involving the asymptomatic household contacts. Household contacts of 13 index patients were enrolled in the study. Contact history and clinical symptoms of the household contacts were recorded by standardized questionnaires. Blood samples of patients and household contacts were collected at least 28 days after symptom onset in the index patients or household exposure in the contacts for SARS-associated coronavirus (SARS-CoV) IgG testing. On the basis of this investigation, 29 persons (25 adults and 4 children) were identified as having had unprotected exposure to the index cases before infection-control practices were implemented. Laboratory evaluation of clinical specimens showed no evidence of transmission of SARS-CoV infection to any contacts. This investigation demonstrated that subclinical transmission among household contacts was low in the described setting.

Type
Research Article
Information
Epidemiology & Infection , Volume 133 , Issue 6 , December 2005 , pp. 1119 - 1122
Copyright
2005 Cambridge University Press