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The streptolysins of various groups and types of haemolytic streptococci; a serological investigation

Published online by Cambridge University Press:  15 May 2009

E. W. Todd
E. W. Todd
Affiliation:
From the Belmont Laboratories (London County Council), Sutton, Surrey
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1. Group A haemolytic streptococci produce two distinct varieties of streptolysin:

(a) Streptolysin O which is oxygen sensitive.

(b) Streptolysin S which is serum extractable.

These two streptolysins are neutralized by separate antibodies which appear to be entirely unrelated.

2. Neutralization experiments in vitro with group A antistreptolysin O show that streptolysin O is formed by strains belonging to groups A, C (human) and G; it is not formed by strains belonging to groups B, C (animal), D, E, H and K. The relation of group F strains to streptolysin O is at present uncertain.

3. Group A strains of different serological types all produce streptolysin S neutralizable by group A antistreptolysin S. Strains belonging to groups B, C, D, E, F, G, H and K do not produce streptolysin S neutralizable by group A antistreptolysin S. The neutralization is therefore group-specific but not type-specific.

Type
Research Article
Information
Journal of Hygiene , Volume 39 , Issue 1 , January 1939 , pp. 1 - 11
Copyright
Copyright © Cambridge University Press 1939

References

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