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Teratogenicity of the Palyam serogroup orbiviruses in the embryonated chicken egg model

Published online by Cambridge University Press:  15 May 2009

T. Whistler  and
R. Swanepoel
T. Whistler
Affiliation:
National Institute for Virologyand Department of Virology, University of the Witwatersrand, Sandringham 2131, Republic of South Africa
R. Swanepoel
Affiliation:
National Institute for Virologyand Department of Virology, University of the Witwatersrand, Sandringham 2131, Republic of South Africa
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Summary

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Embryonated chicken eggs were used as a model for assessing the teratogenic potential of several Palyam serogroup orbiviruses. Infection of 4-day-old embryonated chicken eggs via the yolk sac with eight of the viruses resulted in deaths or congenital deformities which included retarded development, arthrogryposis and reduced feathering. Statistical analysis showed that the viruses could be divided into three groups: those that caused death (Gweru virus isolates 866/77 and 1726/7776 and Apies River virus), those that caused deaths only when large amounts of virus were inoculated (Gweru isolate AR11869 and Marondera virus) and those that caused death and deformities (Abadina, Kasba, Nyabira, Petevo and Vellore viruses). Differences in pathogenic potential were noted between isolates identified as the same serotype by serological tests.

Type
Research Article
Information
Epidemiology & Infection , Volume 106 , Issue 1 , February 1991 , pp. 179 - 188
Copyright
Copyright © Cambridge University Press 1991

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