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The toxicity of chlorophacinone and warfarin to house mice (Mus musculus)

Published online by Cambridge University Press:  15 May 2009

Mogens Lund
Mogens Lund
Affiliation:
Statens Skadedyrlaboratorium, Skovbrynet 14, DK-2800, Lyngby, Denmark
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Summary

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Individually caged house mice (Mus m. musculus) were fed 0·025% warfarin (3(2-acetyl-l-phenylethyl)-4-hydroxycoumarin) or 0·025% chlorophacinone (2-(l-(p-chlorophenyl)-l-phenyl) acetyl-l,3-indandione) for periods varying from 1 to 21 days. In all, 320 mice, 160 of each sex, were tested.

A significant difference was found between the mortalities obtained by the two compounds. In feeding periods varying from 1–5 days chlorophacinone produced a mortality of 60–85 % and warfarin only 5–75 %. Five per cent, however, did survive 21 days feeding on each compound.

A great variation in the susceptibility of individual mice was established for chlorophacinone as well as for warfarin.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 1 , March 1971 , pp. 69 - 72
Copyright
Copyright © Cambridge University Press 1971

References

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