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Trials with a live attenuated rubella virus vaccine, Cendehill strain

Published online by Cambridge University Press:  15 May 2009

L. Grant ,
E. A. Belle ,
G. Provan ,
S. D. King  and
M. M. Sigel
L. Grant
Affiliation:
Department of Microbiology, University of the West Indies Kingston, Jamaica
E. A. Belle
Affiliation:
Department of Microbiology, University of the West Indies Kingston, Jamaica
G. Provan
Affiliation:
Department of Microbiology, University of the West Indies Kingston, Jamaica
S. D. King
Affiliation:
Department of Microbiology, University of the West Indies Kingston, Jamaica
M. M. Sigel
Affiliation:
Department of Microbiology, University of Miami, Coral Gables, Florida
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Summary

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This report summarizes closed, family, and open studies conducted sequentially over a 10 month period with the Cendehill rubella virus vaccine in more than 16,000 children and adolescents. This strain of rubella was attenuated by serial propagation on primary rabbit kidney cell cultures. Inoculation of the Cendehill vaccine produced seroconversion in 97% of the 3589 susceptible (seronegative) vaccinated persons. There was no spread of the virus to susceptible controls living in close contact with those vaccinated. The vaccine was well tolerated. No arthritis or arthralgia occurred in 860 female subjects 13–18 years of age who were included in the study. The Cendehill vaccine would appear to meet the requirements of an acceptable vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 505 - 510
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Cooper, L. Z., Ziring, P. R., Weiss, H. J., Matters, B. A. & Krugman, S. (1969). Transient arthritis after rubella vaccination. American Journal of Diseases of Children 118, 218–25.Google ScholarPubMed
Dudgeon, J. A., Marshall, W. C., Peckham, C. S. & Hawkins, G. T. (1969). Clinical and laboratory studies with rubella vaccines in adults. British Medical Journal i, 271–6.CrossRefGoogle Scholar
Farquhar, J. D. & Corbetjer, J. E. (1969). Clinical experience with Cendehill rubella vaccine in mature women. American Journal of Diseases of Children 118, 266–8.Google ScholarPubMed
Gold, J. A., Prinzie, A. & Mckee, J. (1969). Adult women vaccinated with rubella vaccine. American Journal of Diseases of Children 118, 264–5.CrossRefGoogle ScholarPubMed
Horstmann, D. M., Byrne, E. B., Ryan, J. M., Randolph, M. F., Liebhaber, H. & McCollum, R. W. (1969). Comparison of HPV-77/D-5 and Cendehill strain vaccines in adult women. International Symposium on rubella vaccines, London 1968. Symposia Series on Immunobiological Standardization, vol. 11, pp. 429–34.Google Scholar
Huygelen, C., Peetermans, J., Colinet, G., Zygraich, N. & Fagard, P. (1969). Production and safety testing of live rubella virus vaccine (Cendehill strain). International Symposium on rubella vaccines, London 1968. Symposia Series on Immunobiological Standardization, vol. 11, pp. 229–36.Google Scholar
Majer, R. (1967). Rubella epidemiological studies and experiences with an attenuated vaccine (‘Cendehill strain’). Helvetica paediatrica acta 22, 579–90.Google ScholarPubMed
Martin, Dupan R., Huygelen, C., Peetermans, J. & Prinzie, A. (1968). Attenuation of rubella virus by serial passage in primary rabbit kidney cells. Paediatric Research 2, 38–42.Google Scholar
Martin, Dupan R., Peetermans, J., Huygelen, C. & Prinzie, A. (1967). Rubella: immunology and vaccination. Revue médicate de la Suisse romande 10, 762–6.Google Scholar
Plotkin, S. A., Farquhar, J., Katz, M., Prinzie, A. & Ingalls, T. H. (1968). An attenuated rubella virus strain adapted to primary rabbit kidney. American Journal of Epidemiology 88, 97–102.CrossRefGoogle ScholarPubMed
Prinzie, A., Huygelen, C., Gold, J. & Farquhar, J. (1969). Clinical evaluation of an experimental live attenuated rubella virus vaccine (Cendehill strain). American Journal of Diseases of Children 118, 172–7.CrossRefGoogle Scholar
Stewart, G. L., Parkman, P. D., Hopps, H. E., Douglas, R. D., Hamilton, J. P. & Meyer, H. M. Jr. (1967). Rubella virus haemagglutination-inhibition test. New England Journal of Medicine 276, 554–7.CrossRefGoogle Scholar