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Vaccination against Hong Kong influenza in Britain, 1968–9: A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines*

Published online by Cambridge University Press:  15 May 2009

D. A. J. Tyrrell ,
Rosemary Buckland ,
D. Rubenstein  and
D. M. Sharpe
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre Laboratories, National Institute for Medical Research, The Ridgeway, London, N. W. 7
Rosemary Buckland
Affiliation:
Clinical Research Centre Laboratories, National Institute for Medical Research, The Ridgeway, London, N. W. 7
D. Rubenstein
Affiliation:
Clinical Research Centre Laboratories, National Institute for Medical Research, The Ridgeway, London, N. W. 7
D. M. Sharpe
Affiliation:
Medical Research Council, 20 Park Crescent, London, WIN 4AL
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Summary

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Studies of the effect of Hong Kong (HK) influenza vaccine were made in adults and children in Great Britain during 1968 and 1969. The vaccines were administered intramuscularly and also by intranasal spray. The serum antibody response was studied in 284 subjects. Most developed rising titres to vaccine given intramuscularly and few to vaccine given intranasally. Deoxycholate-split vaccine was as potent as conventional whole virus vaccine. Antibody titres were maintained for months. Over 4000 subjects in factories, offices and schools were observed during the epidemic. The incidence of disease was not significantly reduced by either form of vaccination. A survey was made of epidemics in boarding schools in which some of the pupils had been vaccinated, in six with commercial polyvalent vaccine and in five with HK; there was a lower incidence of influenza in two schools vaccinated 2 or 4 weeks earlier with HK vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 359 - 368
Copyright
Copyright © Cambridge University Press 1970

References

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