Let \varphi be a primitive, non-periodic substitution. The tiling space \mathcal{T}_\varphi has a finite (non-zero) number of asymptotic composants. We describe the form and make use of these asymptotic composants to define a closely related substitution \varphi^* and prove that for primitive, non-periodic substitutions \varphi and \chi, \mathcal{T}_\varphi and \mathcal{T}_\chi are homeomorphic if and only if {\varphi^*} (or its reverse) and \chi^* are weakly equivalent. We also provide examples indicating that for substitution minimal systems, flow equivalence and orbit equivalence are independent.