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2039 – Multidimensional Scaling Analysis Of The Association Of Snps Related 5-htr2a Signal Pathway And The Phenotype Characteristics Of Major Depression In Chinese Han

Published online by Cambridge University Press:  15 April 2020

K. Yang  and
H. Li
K. Yang
Affiliation:
Department of Psychiatry, Tianjin Anding Hospital & Tianjin Mental Health Institute, Tianjin, Zhengzhou, China
H. Li
Affiliation:
Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China

Abstract

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Objective

Our aim was to explore the possible association between four SNPs related with 5-HTR2A signal pathways and phenotype characteristics of major depressive disorder (MDD) in Chinese Han.

Methods

194 patients with recurrent major depressive episodes were from Chinese Han origin. 4 SNPs were detected with LDR (ligase detection reaction). The multidimensional scaling analysis was use for testing the association between different genotypes of four SNPs (5-HTR2A rs6311, Gβ3 rs5443, ADCY9 rs2230739 and PDE1A rs1549870 related with 5-HT2A signal pathway) and phenotype characteristic of MDD.

Results

The multidimensional scaling illustrated: rs6311CC, rs5443CC and rs1549870GG with the certainly-existed fundamental symptom 2 were in the same zone; rs6311CC and accessory symptoms 7, and rs6311CC and depressive episode with psychotic symptoms and repeated episodes are in the same zone. The results showed rs6311CC had a close correlation with depressive symptoms.

Conclusions

It is concluded that rs6311 may be the functional point of the 5-HT2A gene in MDD; It is presumed that different genotypes of rs5443 and rs2230739 can modulate the second message signal pathways in MDD.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1253
Copyright
Copyright © European Psychiatric Association 2012
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